Selective Access to 4-Substituted 2-Aminothiazoles and 4-Substituted 5-Thiocyano-2-aminothiazoles from Vinyl Azides and Potassium Thiocyanate Switched by Palladium and Iron Catalysts
Selective Access to 4-Substituted 2-Aminothiazoles and 4-Substituted 5-Thiocyano-2-aminothiazoles from Vinyl Azides and Potassium Thiocyanate Switched by Palladium and Iron Catalysts
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DOI：
10.1021/acs.orglett.5b02152
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发表时间：
2015-10-02
期刊：
影响因子：
5.2
通讯作者：
Yu, Yongping
中科院分区：
文献类型：
--
作者：
Chen, Binhui;Guo, Shanshan;Yu, Yongping
以乙酸钯(II)为催化剂，溴化铁(III)为催化剂，以乙烯基叠氮化物和硫氰酸钾为原料，合成了4-取代2-氨基噻唑和4-取代5-硫氰基-2-氨基噻唑。使用容易获得的原料，高选择性，以及温和的反应条件使这种实用的方法特别吸引人。
A highly selective construction of 4-substituted 2-aminothiazoles and 4-substituted 5-thiocyano-2-aminothiazoles, respectively, catalyzed by palladium(II) acetate and promoted by iron(III) bromide from vinyl azides and potassium thiocyanate has been developed. Use of readily available starting materials, high selectivity, as well as mild reaction conditions make this practical method particularly attractive.