Nephrotoxicity Evaluation on Cisplatin Combined with 5-HT(3) Receptor Antagonists: A Retrospective Study.
Nephrotoxicity Evaluation on Cisplatin Combined with 5-HT(3) Receptor Antagonists: A Retrospective Study.
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DOI：
10.1155/2018/1024324
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发表时间：
2018
影响因子：
--
通讯作者：
Wu X
中科院分区：
文献类型：
--
作者：
Kou W;Qin H;Hanif S;Wu X
5-HT3受体拮抗剂恩丹西酮与顺铂合用对小鼠有肾毒性作用已有报道，但有关其对患者肾毒性作用的解释很少。本研究旨在探讨5-HT3受体拮抗剂是否能增加或加重顺铂所致肾毒性的发生率。我们回顾了2010年1月至2015年12月用顺铂(⩾60 mg/m2)作为首次化疗方案并联合5-HT3受体拮抗剂(即恩丹西酮、托烷司琼或雷莫司琼，每种5-HT3受体拮抗剂各200例)治疗的600例肿瘤患者。在多变量模型中评估顺铂剂量、基线肌酐清除量和其他独立危险因素，如患者的年龄、性别、PS评分和体重与肾毒性相关。顺铂+恩丹西酮组⩾-2级血肌酐升高的发生率显著高于顺铂+托烷司琼组(P=0.0 4)，而顺铂+恩丹西酮组与顺铂+雷莫司琼组比较差异无统计学意义(P=0.3)。顺铂剂量和肿瘤类型是肾毒性发生的独立危险因素。顺铂剂量越大、恩丹西酮与顺铂联合应用越频繁，肾毒性发生率越高；托烷司琼对肾功能的影响相对较轻，提示托烷司琼是顺铂化疗过程中较好的替代方案。
5-HT3 receptor antagonist (ondansetron) has been reported to have nephrotoxic effect when combined with cisplatin in mice; however, little evidence exists in explaining its nephrotoxic effects on patients. The aim of this present study was to investigate whether 5-HT3 receptor antagonist could enhance or aggravate the incidence of cisplatin-induced nephrotoxicity in patients. We retrospectively reviewed 600 tumor patients which were treated with cisplatin (⩾60 mg/m2) as a first-time chemotherapy and combined with 5-HT3 receptor antagonist (i.e., ondansetron, tropisetron, or ramosetron, each kind of 5-HT3 receptor antagonist contains 200 cases) between January 2010 and December 2015. Cisplatin dosing, the baseline creatinine clearance, and other independent risk factors such as patient's age, sex, PS score, and weight associated with nephrotoxicity were evaluated in a multivariable model. The incidence of Grade ⩾ 2 serum creatinine elevation in cisplatin + ondansetron group was significantly higher than cisplatin + tropisetron group (P = 0.04), but no significant difference was found between cisplatin + ondansetron group and cisplatin + ramosetron group (P = 0.3). It was also found that cisplatin dosage and tumor type were independent risk factors in the development of nephrotoxicity. Higher cisplatin dosage and regular use of ondansetron combined with cisplatin are more likely to increase the incidence of nephrotoxicity; tropisetron showed the relatively mild effect on kidney function, suggesting that tropisetron is a preferable alternative in the process of cisplatin chemotherapy.
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影响因子：
6
作者：
Ciarimboli, Giuliano;Deuster, Dirk;Schlatter, Eberhard
通讯作者：
Schlatter, Eberhard
影响因子：
2.8
作者：
Tzvetkov, M. V.;Saadatmand, A. R.;Brockmoeller, J.
通讯作者：
Brockmoeller, J.
影响因子：
19.6
作者：
Wei, Q.;Dong, G.;Dong, Z.
通讯作者：
Dong, Z.
DOI：
10.1158/1078-0432.ccr-10-0949
发表时间：
2010-08-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Franke RM;Kosloske AM;Lancaster CS;Filipski KK;Hu C;Zolk O;Mathijssen RH;Sparreboom A
通讯作者：
Sparreboom A
影响因子：
8.4
作者：
Bodnar, Lubomir;Wcislo, Gabriel;Szczylik, Cezary
通讯作者：
Szczylik, Cezary