The ADC API: A Web API for the Programmatic Query of the AIRR Data Commons.
The ADC API: A Web API for the Programmatic Query of the AIRR Data Commons.
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DOI：
10.3389/fdata.2020.00022
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发表时间：
2020
影响因子：
3.1
通讯作者：
Cowell LG
中科院分区：
文献类型：
--
作者：
Christley S;Aguiar A;Blanck G;Breden F;Bukhari SAC;Busse CE;Jaglale J;Harikrishnan SL;Laserson U;Peters B;Rocha A;Schramm CA;Taylor S;Vander Heiden JA;Zimonja B;Watson CT;Corrie B;Cowell LG
适应性免疫受体库(AIRR)社区是一个研究驱动的组织，它正在建立一套明确的社区接受的数据和元数据标准；基于标准的参考实施工具；以及基础设施的政策和实践，以支持存储、管理、存储和使用来自B细胞和T细胞受体库的高通量测序数据(AIRR-SEQ数据)。AIRR data Commons是一个分布式数据存储库系统，它使用通用的数据模型、通用的查询语言和通用的互操作性格式来存储、查询和下载AIRR-seq数据。这里描述了AIRR数据共享的主要技术标准，包括用于指令表和重排的AIRR数据模型、用于编程查询数据存储库的AIRR数据共享(ADC)API、ADC API服务的参考实现以及用于查询和验证支持ADC API的数据存储库的工具。通过实现数据模型和API，AIRR-seq数据存储库可以成为AIRR数据公地的一部分。AIRR数据共享允许AIRR-seq数据被重新用于新的分析，并使研究人员能够发现关于适应性免疫系统的新的生物学见解。
The Adaptive Immune Receptor Repertoire (AIRR) Community is a research-driven group that is establishing a clear set of community-accepted data and metadata standards; standards-based reference implementation tools; and policies and practices for infrastructure to support the deposit, curation, storage, and use of high-throughput sequencing data from B-cell and T-cell receptor repertoires (AIRR-seq data). The AIRR Data Commons is a distributed system of data repositories that utilizes a common data model, a common query language, and common interoperability formats for storage, query, and downloading of AIRR-seq data. Here is described the principal technical standards for the AIRR Data Commons consisting of the AIRR Data Model for repertoires and rearrangements, the AIRR Data Commons (ADC) API for programmatic query of data repositories, a reference implementation for ADC API services, and tools for querying and validating data repositories that support the ADC API. AIRR-seq data repositories can become part of the AIRR Data Commons by implementing the data model and API. The AIRR Data Commons allows AIRR-seq data to be reused for novel analyses and empowers researchers to discover new biological insights about the adaptive immune system.