Tissue factor pathway inhibitor and the risk of recurrent venous thromboembolism
Tissue factor pathway inhibitor and the risk of recurrent venous thromboembolism
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DOI：
10.1160/th05-06-0412
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发表时间：
2005-10-01
影响因子：
6.7
通讯作者：
Eichinger, S
中科院分区：
文献类型：
--
作者：
Hoke, M;Kyrle, PA;Eichinger, S
组织因子途径抑制物（TFPI）调节因子X活化。低TFPI是首次静脉血栓形成的危险因素。我们评估低TFPI是否会增加复发性静脉血栓栓塞（VTE）的风险。在611例首次发生自发性VTE的患者中测定了TFPI游离抗原，这些患者在停用抗凝剂后进行了前瞻性随访。终点为症状性复发性VTE。TFPI水平升高的患者复发的相对风险（RR）从1.0（95% CI 0.4-2.6）增加
Tissue factor pathway inhibitor (TFPI) regulates factor X activation. LowTFPI is a risk factor for a first venous thrombosis. We evaluated whether lowTFPI confers an increased risk of recurrent venous thromboembolism (VTE). TFPI-free antigen was measured in 611 patients with a first spontaneous VTE, and who were prospectively followed after withdrawal of anticoagulation. The endpoint was symptomatic recurrent VTE. The relative risk (RR) of recurrence increased from 1.0 (95% CI 0.4-2.6) in patients with TFPI levels