Melanin concentrating hormone. III. Melanin concentrating hormone (MCH): the message sequence.
Melanin concentrating hormone. III. Melanin concentrating hormone (MCH): the message sequence.
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黑色素浓缩激素。
DOI：
10.1016/0024-3205(89)90501-8
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发表时间：
1989
期刊：
影响因子：
6.1
通讯作者：
Hadley,ME
中科院分区：
文献类型：
--
作者：
Castrucci,AM;Lebl,M;Hruby,VJ;Matsunaga,TO;Hadley,ME
黑色素浓集激素（MCH）是由硬骨鱼脑垂体神经垂体分泌的下丘脑合成的十七肽。MCH刺激硬骨鱼黑素细胞内的黑素体聚集，但也表现出对四足动物（青蛙和蜥蜴）黑素细胞的类似MSH（黑素体分散）的活性。我们已经合成了一些MCH类似物，以确定刺激鱼或四足动物黑素细胞中黑素体聚集或分散所需的一级结构的基本特征。这些类似物对脊椎动物黑素细胞的效力和作用的分析，并证明这两种活动具有不同的结构要求。
Melanin concentrating hormone (MCH) is a heptadecapeptide synthesized by the hypothalamus and secreted by the neurohypophysis of the teleost pituitary gland. MCH stimulates melanosome aggregation within teleost melanocytes but also exhibits MSH-like (melanosome dispersing) activity on tetrapod (frog and lizard) melanocytes. We have synthesized a number of MCH analogues to determine the essential features of the primary structure necessary to stimulate either melanosome aggregation or dispersion in fish or tetrapod melanocytes, respectively. An analysis of the potencies and actions of these analogues on vertebrate melanocytes is provided and demonstrates that the two activities have different structural requirements.