Mechanisms of RIG-I-Like Receptor Activation and Manipulation by Viral Pathogens
Mechanisms of RIG-I-Like Receptor Activation and Manipulation by Viral Pathogens
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DOI：
10.1128/jvi.03370-13
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发表时间：
2014-05-01
影响因子：
5.4
通讯作者：
Gack, Michaela U.
中科院分区：
文献类型：
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作者：
Gack, Michaela U.
rig - i样受体（RLRs）在宿主对多种病毒病原体的防御中发挥重要作用。自从它们被发现以来，人们对这些细胞质病毒RNA受体如何感知病毒感染并协调抗病毒先天免疫的分子细节有了更多的了解。有趣的是，除了病毒RNA结合外，rlr的快速激活还需要一系列的翻译后修饰（PTMs），反过来，也需要一系列的翻译后修饰（PTMs）来预防异常的先天免疫信号。最近的发现表明，病毒操纵rlr的ptm以逃避先天免疫检测。本文重点介绍了这个快速发展领域的一些最新发现。
RIG-I-like receptors (RLRs) play important roles in the host defense to numerous viral pathogens. Since they were discovered, much light has been shed on the molecular details of how these cytoplasmic viral RNA receptors sense viral infection and orchestrate antiviral innate immunity. Intriguingly, in addition to viral RNA binding, a series of posttranslational modifications (PTMs) is required for the rapid activation of RLRs and, inversely, for the prevention of aberrant innate immune signaling. Recent discoveries have shown that viruses manipulate the PTMs of RLRs to escape innate immune detection. This article highlights some of these recent findings in this fast-evolving field.