Sulindac inhibits the rate of growth and appearance of colon tumors in the rat.
Sulindac inhibits the rate of growth and appearance of colon tumors in the rat.
复制标题
舒林酸抑制大鼠结肠肿瘤的生长速度和出现。
作者：
Stewart Skinner;Angela G. Penney;Paul E. O'Brien
Sulindac（顺-5-氟-2-甲基-1-[对-（甲基亚砜基）苄基]茚-3-乙酸）是一种前列腺素合成抑制剂，据报道可导致家族性大肠息肉病和加德纳综合征患者结肠息肉消退。我们观察了舒林酸对大鼠原发性结肠癌生长的影响。对18只大鼠反复皮下注射二甲肼诱导结肠肿瘤。通过剖腹和结肠镜检查测量每个肿瘤的位置和直径。大鼠随机接受舒林酸（10 mg/kg）每日2次或对照剂（0.5%甲基纤维素）。治疗4周后，再次记录结肠肿瘤的位置和大小。在接受舒林达克治疗的8只大鼠中，未发现新的肿瘤，而在10只对照大鼠中，治疗后发现了13个新的肿瘤。与接受舒林达克治疗的大鼠（14个肿瘤9.3 mm）相比，对照组（26个肿瘤56.4 mm）的肿瘤大小明显增加。我们报道舒林酸抑制大鼠结肠肿瘤的发育和生长速度。
Sulindac (cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl) benzylidene] indene-3-acetic acid), an inhibitor of prostaglandin synthesis, has been reported to cause regression of colon polyps in patients with familial polyposis coli and Gardner's syndrome. We examined the effect of sulindac on the growth of primary colon carcinomas in rats. Colon tumors were induced in 18 rats by repeated subcutaneous administration of dimethylhydrazine. The site and diameter of each tumor were measured via laparotomy and colonoscopy. Rats were randomized to receive either sulindac (10 mg/kg) twice daily or vehicle (0.5% methylcellulose). After 4 weeks of treatment, the site and size of tumors in the colon were again recorded. In eight rats receiving sulindac, no new tumors were identified, while in 10 control rats, 13 additional tumors were found after treatment. There was a significantly greater increase in size of the tumors in the control group (56.4 mm for 26 tumors) compared with the rats receiving sulindac (9.3 mm for 14 tumors). We report that sulindac inhibits the rate of development and the rate of growth of colon tumors in the rat.
前列腺素 E2 抑制腹膜巨噬细胞的抗原呈递细胞功能。
DOI：
10.1016/0022-4804(88)90108-4
发表时间：
1988
期刊：
The Journal of surgical research
影响因子：
--
作者：
Stephan,RN;Conrad,PJ;Saizawa,M;Dean,RE;Chaudry,IH
通讯作者：
Chaudry,IH
十六种已建立的源自人肺、结肠、前列腺和卵巢肿瘤的细胞系中前列腺素生物合成的概况。
影响因子：
11.2
作者：
Hubbard,WC;Alley,MC;McLemore,TL;Boyd,MR
通讯作者：
Boyd,MR