Post-hatching syrinx development in the zebra finch: an analysis of androgen receptor, aromatase, estrogen receptor alpha and estrogen receptor beta mRNAs.
Post-hatching syrinx development in the zebra finch: an analysis of androgen receptor, aromatase, estrogen receptor alpha and estrogen receptor beta mRNAs.
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斑胸草雀孵化后鸣管发育：雄激素受体、芳香酶、雌激素受体 α 和雌激素受体 β mRNA 的分析。
DOI：
10.1007/s00359-004-0577-5
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Wade,Juli
中科院分区：
文献类型：
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作者：
Veney,SeanL;Wade,Juli
在斑马雀中，雄性的发声器官(空洞)比雌性的大。关于导致这种二型性的具体机制尚不清楚，但可能涉及孵化后发育早期类固醇激素作用的性别差异。分别于孵化后第3、10、17天检测雄激素受体(AR)、芳香化酶(AROM)、雌激素受体α(ERα)和雌激素受体β(ERβ)的mRNAs分布。未检测到AROM或ERα基因的特异性表达。相反，在形成骨的软骨细胞中检测到ERβ。随着软骨细胞的肥大，这种表达的密度随着年龄的增长而增加，但性别之间没有差异。综上所述，这些数据表明雌激素可能作用于软骨/骨，雄激素可能作用于孵化后早期的肌肉纤维，从而影响空洞的形态。然而，脊髓空洞中类固醇受体mRNA的表达没有性别差异，这表明，与控制SONG的前脑区域类似，雄激素和雌激素与其受体的相互作用不足以诱导该器官的完全性别分化。
In zebra finches, the vocal organ (syrinx) is larger in males than in females. Specific details about the mechanisms responsible for this dimorphism are not known, but may involve sex differences in steroid hormone action early in post-hatching development. The distribution of androgen receptor (AR), aromatase (AROM), estrogen receptor α (ERα), and estrogen receptor β (ERβ) mRNAs was examined at post-hatching days 3, 10 and 17. A low level of AR was equivalently expressed in the syrinx muscles of both sexes at all three ages. We detected no specific expression of AROM or ERα mRNAs. In contrast, ERβ mRNA was detected in chondrocytes of the forming bone. The density of this expression increased with age as the chondrocytes hypertrophied, but did not differ between the sexes. Taken together, these data suggest that estrogens may act on cartilage/bone, and androgens may act on muscle fibers in early post-hatching development to influence syrinx morphology. However, the lack of a sex difference in steroid receptor mRNA expression in the syrinx suggests that, similar to the forebrain regions that control song, the interaction of androgens and estrogens with their receptors is not sufficient to induce full sexual differentiation of this organ.