Antihyperlipidemic effect of D-pinitol on streptozotocin-induced diabetic Wistar rats
Antihyperlipidemic effect of D-pinitol on streptozotocin-induced diabetic Wistar rats
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DOI：
10.1002/jbt.20218
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发表时间：
2008-01-01
影响因子：
3.6
通讯作者：
Prince, P. Stanely Mainzen
中科院分区：
文献类型：
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作者：
Gecthan, P. K. M. Anu;Prince, P. Stanely Mainzen
D-pinitol （3- o -甲基-细肌醇）是传统抗糖尿病植物九重干的一种活性成分，据称具有类似胰岛素的作用。本研究旨在探讨d -蒎醇对链脲佐菌素（STZ）诱导的糖尿病Wistar大鼠血脂和脂蛋白的影响。以40 mg/kg体重单次腹腔注射STZ致11型糖尿病大鼠。stz诱导的糖尿病大鼠血糖、血清、肝、肾、心、脑的总胆固醇、甘油三酯、游离脂肪酸和磷脂水平均显著（p < 0.05）升高。stz诱导的糖尿病大鼠经口服D-pinitol后，血清、肝、肾、心、脑的血糖、总胆固醇、甘油三酯、游离脂肪酸、磷脂水平均显著降低（p < 0.05），低密度脂蛋白（LDL）、极低密度脂蛋白（VLDL）胆固醇水平显著升高，高密度脂蛋白（HDIL）胆固醇水平显著降低（p < 0.05）。d -蒎醇还能显著降低糖尿病大鼠血清LDL和VLDL胆固醇水平(1)< 0.05，显著升高HDL胆固醇水平（p < 0.05）。因此，本研究清楚地显示了d -蒎醇对stz诱导的II型糖尿病大鼠的降血脂作用。(C) 2008 Wiley期刊有限公司
D-pinitol (3-O-methyl-chiroinositol), an active principle of the traditional antidiabetic plant, Bougainvillca spectabilis, is claimed to exert insulinlike effects. This study was undertaken to evaluate the effect of D-pinitol on lipids and lipoproteins in streptozotocin (STZ)-induced diabetic Wistar rats. Rats were made type 11 diabetic by single intraperitoneal injection of STZ at a dose of 40 mg/kg body weight. STZ-induced diabetic rats showed significant (p < 0.05) increase in the levels of blood glucose and total cholesterol, triglycerides, free fatty acids, and phospholipids in serum, liver, kidney, heart, and brain. The levels of low-density lipoprotein (LDL) and very lowdensity lipoprotein (VLDL) cholesterol were significantly increased, and the level of high-density lipoprotein (HDIL) cholesterol was significantly decreased in diabetic rats Oral administration of D-pinitol to STZ-induced diabetic rats showed significant (p < 0.05) decrease in the levels of blood glucose and total cholesterol, triglycerides, free fatty acids, and phospholipids in serum, liver, kidney, heart, and brain. The D-pinitol also lowered significantly (1) < 0.05) LDL and VLDL cholesterol levels and increased significantly (p < 0.05) HDL cholesterol levels in the serum of diabetic rats. Thus, the present study clearly showed the antihyperlipidemic effect of D-pinitol in STZ-induced type II diabetic rats. (C) 2008 Wiley Periodicals, Inc.