Terretonin, ophiobolin, and drimane terpenes with absolute configurations from an algicolous Aspergillus ustus
Terretonin, ophiobolin, and drimane terpenes with absolute configurations from an algicolous Aspergillus ustus
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来自海藻曲霉的具有绝对构型的 Terretonin、ophiobolin 和 drimane 萜烯
DOI：
10.1039/c2ra22701k
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发表时间：
2013-01-01
期刊：
影响因子：
3.9
通讯作者：
Ji, Nai-Yun
中科院分区：
文献类型：
--
作者：
Liu, Xiang-Hong;Miao, Feng-Ping;Ji, Nai-Yun
一种新的半萜，1，2-二氢terretonin F（2），五种新的二倍半萜，（6 α）-21-deoxyophiobolin G（3），（6 α）-16，17-dihydro-21-deoxyophiobolin G（4），ophiobolin U（5），ophiobolin V（6），和ophiobolin W（7），两种新的倍半萜，从海洋绿色松藻新鲜组织中分离得到（E，E）-6，7-环氧-2，4-辛二烯酸的（6-甲氧基丙烯酸内酯-B）酯（13和14）和12种已知萜类化合物（1，8-12和15-20）。通过核磁共振、质谱和量子化学计算确定了它们的结构和绝对构型。部分菌株具有抗菌活性和对卤虫的毒性。
One new meroterpene, 1,2-dihydroterretonin F (2), five new sesterterpenes, (6 alpha)-21-deoxyophiobolin G (3), (6 alpha)-16,17-dihydro-21-deoxyophiobolin G (4), ophiobolin U (5), ophiobolin V (6), and ophiobolin W(7), two new sesquiterpenes, (6-strobilactone-B) esters of (E,E)-6,7-epoxy-2,4-octadienoic acids (13 and 14), and twelve known terpenes (1, 8-12, and 15-20) were isolated from Aspergillus ustus, a fungus from the fresh tissue of marine green alga Codium fragile. Their structures and absolute configurations were identified by NMR and mass spectroscopic methods as well as quantum chemical calculations. Some of the isolates exhibited antibacterial activity and brine shrimp toxicity.