2 CLASSES OF SINGLE-INPUT X-CELLS IN CAT LATERAL GENICULATE-NUCLEUS .2. RETINAL INPUTS AND THE GENERATION OF RECEPTIVE-FIELD PROPERTIES
2 CLASSES OF SINGLE-INPUT X-CELLS IN CAT LATERAL GENICULATE-NUCLEUS .2. RETINAL INPUTS AND THE GENERATION OF RECEPTIVE-FIELD PROPERTIES
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DOI：
10.1152/jn.1987.57.2.381
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发表时间：
1987-02-01
影响因子：
2.5
通讯作者：
MASTRONARDE, DN
中科院分区：
文献类型：
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作者：
MASTRONARDE, DN
直接记录猫外侧膝状体(LGN)细胞的视网膜输入，以研究两类LGN X细胞的特性基础：XS(单一)和XL(滞后)。在非刺激活动期间，用交叉相关图评估从特定的同时记录的神经节细胞到LGN细胞的兴奋性或抑制性输入的存在。由于相邻的神经节细胞不是独立放电的，视网膜生发相关图中的特征可以以两种方式出现，必须通过神经节细胞对LGN细胞的直接影响或通过该神经节细胞与作为LGN细胞兴奋性或抑制性输入的其他神经节细胞之间的相关放电来区分。有可能确定相关图特征的来源，因为表明视网膜再生效应的特征在时间和强度上与仅由视网膜相关放电产生的特征明显不同。LGN细胞和兴奋性视网膜输入之间的相关图的特征是LGN细胞在神经节细胞放电后适当的潜伏期有一个尖锐的峰值。抑制性输入的特征是在神经节细胞放电后LGN细胞的放电率下降。通常，这种下降持续10-40ms，随后LGN细胞的放电频率持续增加，这可能反映了抑制后的反弹。XS细胞只有一个视网膜X输入，在刺激和非刺激活动中，其兴奋效应引起了LGN细胞的大部分尖峰。没有确凿的证据表明，任何XS细胞接受了来自Y细胞或同一中心符号的其他X细胞的兴奋性视网膜输入。通常有证据表明，视网膜中央符号相反的X细胞与XS细胞的感受野高度重叠，但很少有证据表明Y细胞对XS细胞有抑制作用。XL-细胞也只有一个单一的兴奋性输入，但这种X输入的影响相对较弱，仅导致LGN细胞的一小部分尖峰，通常在维持活动期间为17%，在视觉刺激期间为29%。在输入的兴奋效应之后，立即对XL-细胞产生强烈的抑制。XL细胞也被与兴奋性输入相邻(最近的邻居)的相同中心标志的视网膜X细胞抑制。这两种抑制作用的强度和潜伏期都表明这种抑制是双突触的。
The retinal inputs to cells in the cat's lateral geniculate nucleus (LGN) were directly recorded to study the basis for the properties of two classes of LGN X-cells: Xs (single) and XL (lagged). The presence of excitatory or inhibitory input to an LGN cell from a particular simultaneously recorded ganglion cell was assessed with cross-correlograms during unstimulated activity. Because neighboring ganglion cells do not fire independently, features in a retinogeniculate correlogram can arise in two ways that must be distinguished by a direct effect of the ganglion cell on the LGN cell, or by correlated firing between that ganglion cell and some other ganglion cell that is an excitatory or inhibitory input to the LGN cell. It was possible to determine the origin of correlogram features because features indicating a retinogeniculate effect were distinctly different in timing and strength from features arising solely from correlated firing in the retina. The characteristic feature in a correlogram between an LGN cell and an excitatory retinal input was a sharp peak in LGN cell firing rate at the appropriate latency after the firing of the ganglion cell. The characteristic feature for an inhibitory input was a dip in LGN cell firing rate after the firing of the ganglion cell. Typically, this dip lasted 10-40 ms and was followed by a prolonged enhancement in LGN cell firing rate, which may reflect a postinhibitory rebound. XS-cells had a single retinal X input whose excitatory effect caused most of the LGN cell's spikes during stimulated and unstimulated activity. There was no conclusive evidence that any XS-cell received excitatory retinal input from either Y-cells or other X-cells of the same center sign. There was usually evidence for inhibition of XS-cells by retinal X-cells of opposite center sign with receptive fields highly overlapping that of the XS-cell, but rarely evidence for inhibition by Y-cells. XL-cells also had only a single excitatory input, but this X input had a relatively weak effect that caused only a minority of the LGN cell's spikes, typically 17% during maintained activity and 29% during visual stimulation. The input's excitatory effect was immediately followed by strong inhibition of the XL-cell. XL-cells were also inhibited by retinal X-cells of the same center sign that were adjacent (nearest neighbors) to the excitatory input. The strength and latency of both of these inhibitory effects indicate that the inhibition was disynaptic.(ABSTRACT TRUNCATED AT 400 WORDS)