Design and synthesis of novel substituted quinazoline derivatives as antileishmanial agents
Design and synthesis of novel substituted quinazoline derivatives as antileishmanial agents
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DOI：
10.1016/j.bmcl.2009.07.081
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发表时间：
2009-09-15
影响因子：
2.7
通讯作者：
Gupta, Suman
中科院分区：
文献类型：
--
作者：
Agarwal, K. C.;Sharma, Vidisha;Gupta, Suman
以2-（取代亚苄基）四氢萘酮-1（3a-d）和几种取代胍硫酸盐（4a-d）为原料，合成了4-（取代亚苄基）-2-取代-5，6-二氢苯并[h]喹唑啉（5a-p）和4-（取代亚苄基）-2-取代-3，4，5，6-四氢苯并[h]喹唑啉（6a-p）。测试这些化合物的体外抗利什曼原虫活性。化合物6 i、6 f、6 g对杜氏利什曼原虫具有较好的抗利什曼原虫活性。(C)2009爱思唯尔有限公司保留所有权利。
4-(Substituted-benzylidine)-2-substituted-5,6-dihydrobenzo[h]quinazoline (5a-p) and 4-(substituted-benzylidine)-2-substituted-3, 4, 5, 6-tetrahydrobenzo[h]quinazoline (6a-p) have been synthesized from 2-(substituted-benzylidine)tetralone-1(3a-d) and several substituted guanidine sulfates(4a-d). These compounds were tested for their in vitro antileishmanial activity. The compounds 6i, 6f, 6g show promising antileishmanial activity against Leishmania donovani. (C) 2009 Elsevier Ltd. All rights reserved.