Serum Leptin Levels in Patients with Pollen-Induced Allergic Rhinitis
Serum Leptin Levels in Patients with Pollen-Induced Allergic Rhinitis
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DOI：
10.1159/000161581
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发表时间：
2009-01-01
影响因子：
2.8
通讯作者：
Marseglia, Gianluigi
中科院分区：
文献类型：
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作者：
Ciprandi, Giorgio;Filaci, Gilberto;Marseglia, Gianluigi
背景：一些研究已经概述了身体质量指数（BMI）增加与呼吸道过敏性疾病（如哮喘和鼻炎）之间的可能关系。该研究的目的是评估花粉引起的过敏性鼻炎患者的血清瘦素水平，这些患者在花粉季节之外被招募，并作为一组健康对照。方法：本研究纳入75例受试者：41例花粉过敏引起的中重度持续性变应性鼻炎患者和34例正常人。对所有受试者进行前瞻性和连续性评估。对所有受试者进行皮肤点刺试验和血液取样，以评估血清瘦素水平、嗜酸性粒细胞、特异性IgE和鼻腔挑战。结果：按性别分型分析，女性过敏患者血清血清素水平显著高于正常女性（p = 0.031），而男性过敏患者血清素水平与正常男性比较差异无统计学意义（p = 0.9651）。正常（p = 0.0059）和过敏（p = 0.0042）女性血清瘦素水平与年龄显著相关。此外，所有过敏患者的BMI与瘦素水平均有显著相关（p = 0.01）；此外，女性瘦素水平与症状严重程度（p = 0063, r = 0.68）、男性外周嗜酸性粒细胞（p = 0.023, r = 0.49）、两性鼻致敏原阈值剂量（男性：p = 0.0001, r = -0.85；女性：p = 0.0001, r = -0.95）之间也存在显著关系。结论：本初步研究首次提供了花粉季节外花粉致变应性鼻炎女性患者血清瘦素水平显著升高的证据。版权所有2008 S. Karger AG，巴塞尔
Background: Several studies have outlined a possible relationship between an increased body mass index (BMI) and respiratory allergic diseases, such as asthma and rhinitis. The aim of the study was to evaluate the serum leptin levels in a cohort of patients with pollen-induced allergic rhinitis, enrolled outside the pollen season, and in a group of healthy controls. Methods: The study included 75 subjects: 41 patients with moderate-severe persistent allergic rhinitis due to a pollen allergy and 34 normal subjects. All subjects were prospectively and consecutively evaluated. A skin prick test and blood sampling for assessing serum leptin levels, eosinophils, specific IgE, and nasal challenge were performed in all subjects. Results: After analyzing genders separately, female allergic patients showed significantly higher levels than normal females (p = 0.031), whereas the comparison between allergic and normal males was not significant (p = 0.9651). Leptin serum levels were significantly related with age in normal (p = 0.0059) and allergic (p = 0.0042) females. In addition, BMI and leptin levels were significantly correlated (p = 0.01) in all allergic patients; there were other significant relationships between leptin levels and symptom severity in females (p = 0063, r = 0.68), peripheral eosinophils in males (p = 0.023, r = 0.49), and allergen threshold dose at nasal challenge in both genders (males: p = 0.0001, r = -0.85; females: p = 0.0001, r = -0.95). Conclusions: This preliminary study provides the first evidence of significantly higher leptin serum levels in female patients with pollen-induced allergic rhinitis outside the pollen season. Copyright (C) 2008 S. Karger AG, Basel