PERFORMANCE COMPARISON OF SEVERAL PUBLISHED TISSUE NEAR-INFRARED SPECTROSCOPY ALGORITHMS
PERFORMANCE COMPARISON OF SEVERAL PUBLISHED TISSUE NEAR-INFRARED SPECTROSCOPY ALGORITHMS
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DOI：
10.1006/abio.1995.1252
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发表时间：
1995-05-01
影响因子：
2.9
通讯作者：
DELPY, DT
中科院分区：
文献类型：
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作者：
MATCHER, SJ;ELWELL, CE;DELPY, DT
我们收集了人类前臂肌肉、成年大鼠头部和新生仔猪头部的多波长近红外（NIR）衰减光谱，并使用已发表的算法比较四组发色团浓度的变化。我们发现每个数据集的算法结果之间存在差异，特别是在它们对细胞色素氧化酶（cyt-aa(3)）氧化还原变化的估计方面。在将相同的算法应用于三个数据集时，我们也发现了一些差异，这表明在不同生理系统之间转移算法可能存在困难(例如，Kurth, c.d., Steven， J. M., Benaron， D.和Chance， B. (1993) J. Clin。Monit. 9,163 -170)。我们还使用测量血红蛋白吸收光谱和光在组织中传输的扩散模型生成的模拟数据对算法进行了比较。我们发现，虽然来自三组的算法大致一致，但Piantadosi （Piantadosi, c.a. (1993) Methods Toxicol. 2,107 -126）发表的算法对cyt-aa(3)和HbO(2)产生了显著不同的结果。用于产生模拟数据的血红蛋白光谱不准确或建模不正确，或者该算法是错误的。(C) 1995学术出版社，Inc。
We have collected multiwavelength near-infrared (NIR) attenuation spectra on human forearm muscle, the adult rat head, and newborn piglet head to compare the changes in chromophore concentration derived from these data using published algorithms from four groups. We find differences between the results from the algorithms on each data set, particularly in their estimation of cytochrome oxidase (cyt-aa(3)) redox changes. We also find some differences when applying the same algorithm to the three data sets, suggesting possible difficulties in transferring algorithms between different physiological systems (e.g., Kurth, C. D., Steven, J. M., Benaron, D., and Chance, B. (1993) J. Clin. Monit. 9, 163-170). We have also compared the algorithms using simulated data generated using measured hemoglobin absorption spectra and a diffusion model for light transport in tissue. We find that while the algorithms from three groups are in broad agreement, that published by Piantadosi (Piantadosi, C. A. (1993) Methods Toxicol. 2, 107-126) produces significantly different results for cyt-aa(3) and HbO(2). Either the hemoglobin spectra used to produce the simulated data are inaccurate or the modeling is incorrect, or this algorithm is erroneous. (C) 1995 Academic Press, Inc.