Sarcoma botryoides; rhabdomyosarcoma of the bladder.
Sarcoma botryoides; rhabdomyosarcoma of the bladder.
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葡萄状肉瘤；
DOI：
10.1016/s0022-5347(17)65837-3
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发表时间：
1959
期刊：
影响因子：
--
通讯作者：
B. Smith
中科院分区：
文献类型：
--
作者：
B. Smith
术语“葡萄状肉瘤”优于关于主要细胞类型的病理学争论。牢记“葡萄般的”，人们会更频繁、更早地诊断出肿瘤。了解其行为后，预后将会得到改善。 McFarland 在 516 篇参考文献中发现了 119 个适用于泌尿生殖区域肉瘤的术语。它们都是发育不良肿瘤，由泌尿生殖系统胚胎学洗牌中丢失的中胚层细胞引起，丢失的细胞成为通配符（科恩海姆的理论）。那些在很小的时候就表现出野生潜力的肿瘤是快速生长的、明显恶性的松散粘液瘤。如果存在扩展空间，它们往往会变成葡萄状。细胞类型通常是横纹肌肉瘤，但在许多细胞中，未发现或不存在诊断性大嗜酸性细胞和条带。然而，我相信肿瘤本质上是一样的。这包括小女孩阴道的葡萄状肉瘤和小男孩的前列腺肉瘤。肉瘤可能起源于沃尔夫管，在膀胱中，出现在三角区和内道区域的粘膜下层。它们迅速生长，形成珍珠状、息肉状、半透明肿块，但往往局限于膀胱、后尿道和输尿管，直到晚期才深入渗透。远处转移（区域淋巴结、肝脏、肺部）发生较晚。梗阻发生较早，肾功能受损。一旦肿瘤通过手术或渗透逃逸出内脏，快速而大规模的扩展或复发就是常态。基于这种行为，潜在的预后良好。然而，肉眼无法确定肿瘤的边缘，只有膀胱切除术才能治愈该病变。费格特报道
The term sarcoma botryoides is to be preferred to pathologic debate as to the predominant cell type. Keeping" grape-like" in mind, one will diagnose the tumor more frequently and earlier. With an understanding of its behavior, the prognosis will be improved. McFarland found 119 terms applied to sarcomatous tumors of the urogenital area in 516 references. They are all dysontogenetic tumors, arising from mesodermal cells lost in the embryologic shuffle of the genitourinary deck and the lost cells become wild cards (Cohnheim's theory). Those that manifest their wild potential at an early age are rapidly growing, loose myxomatous tumors of marked malignancy. If expansion room is present, they tend to become botryoid. The cell type is frequently rhabdomyosarcoma but in many, the diagnostic large eosinophilic cells and bands are not found or are not present. However, the tumor is, I believe, fundamentally the same. This includes the sarcoma botryoides of the vagina of little girls and the sarcoma of the prostate in the small boy.The sarcomas are probably of wolffian duct origin and in the bladder, arise in the submucosa of the region of the trigone and internal meatus. They grow rapidly forming pearly, polypoid, semi-translucent masses but tend to remain confined to the bladder, posterior urethra, and ureters without infiltration in depth until late. Distant metastases (regional lymph nodes, liver, lungs) occur late. Obstruction occurs early and renal function suffers. Once the tumor escapes the viscus by surgery or penetration, rapid and massive extension or recurrence is the rule. Based on this behavior, the potential prognosis is good. However, the margin of tumor cannot be determined grossly and only cystectomy has resulted in cure of this lesion. Feggetter reported