An Introduction to Membrane Proteins
An Introduction to Membrane Proteins
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DOI：
10.1021/pr200145a
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发表时间：
2011-08-01
影响因子：
4.4
通讯作者：
Elofsson, Arne
中科院分区：
文献类型：
--
作者：
Hedin, Linnea E.;Illergard, Kristoffer;Elofsson, Arne
α-螺旋膜蛋白对于许多生物功能都很重要。由于物理化学的限制，膜蛋白的结构与可溶性蛋白的结构不同。从历史上看，膜蛋白结构被认为或多或少是二维的，由长的、直的、跨膜的平行螺旋相互堆积组成。然而，在过去的十年中，许多新的膜蛋白结构对这一概念提出了质疑。如今，很明显，许多膜蛋白的结构与许多可溶性蛋白的结构同样复杂。在这里，我们回顾这一进展，并讨论其对我们理解膜蛋白生物发生、折叠、进化和生物信息学的影响。
alpha-Helical membrane proteins are important for many biological functions. Due to physicochemical constraints, the structures of membrane proteins differ from the structure of soluble proteins. Historically, membrane protein structures were assumed to be more or less two-dimensional, consisting of long, straight, membrane-spanning parallel helices packed against each other. However, during the past decade, a number of the new membrane protein structures cast doubt on this notion. Today, it is evident that the structures of many membrane proteins are equally complex as for many soluble proteins. Here, we review this development and discuss the consequences for our understanding of membrane protein biogenesis, folding, evolution, and bioinformatics.