Immunoglobulin superfamily receptors and adherens junctions.
Immunoglobulin superfamily receptors and adherens junctions.
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DOI：
10.1007/978-94-007-4186-7_7
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发表时间：
2012-01-01
影响因子：
--
通讯作者：
Takai, Yoshimi
中科院分区：
文献类型：
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作者：
Shimono, Yohei;Rikitake, Yoshiyuki;Takai, Yoshimi
免疫球蛋白（Ig）超家族蛋白以存在Ig样结构域为特征，参与多种细胞功能。类igg结构域形成棒状结构并与其他蛋白质特异性结合的特性使其成为细胞表面受体和细胞粘附分子（CAMs）的理想选择。哺乳动物中的igg - cams和果蝇中的Echinoid是上皮中钙粘蛋白黏着连接的重要组成部分。连接素通过它们的反式相互作用形成细胞-细胞粘附，并将钙粘蛋白招募到连接素启动的细胞-细胞粘附位点，建立粘附连接。随后，连接的粘附分子，闭塞蛋白和粘附蛋白，被招募到粘附连接的顶端，以建立紧密的连接。这些分子通过连接蛋白募集，是通过与许多蛋白质（如连环蛋白和闭塞带蛋白）的直接和间接相互作用，以及连接蛋白诱导的肌动蛋白细胞骨架重组介导的。连接素有助于形成同型和异型类型的细胞连接，如大脑中的突触，眼睛中睫状上皮色素和非色素细胞层之间的接触，睾丸中的支持细胞-精子细胞连接，以及感觉器官中的感觉细胞和支持细胞。此外，连接素与各种细胞表面蛋白，如整合素、生长因子受体和连接素样分子（Necls）的顺式和反式相互作用在许多细胞功能的调节中起重要作用，如细胞极化、运动、增殖、分化、存活和细胞分选。此外，igg - cams与许多人类疾病有关，包括病毒感染、外胚层发育不良、癌症和阿尔茨海默病。
The immunogroblin (Ig) superfamily proteins characterized by the presence of Ig-like domains are involved in various cellular functions. The properties of the Ig-like domains to form rod-like structures and to bind specifically to other proteins make them ideal for cell surface receptors and cell adhesion molecules (CAMs). Ig-CAMs, nectins in mammals and Echinoid in Drosophila, are crucial components of cadherin-based adherens junctions in the epithelium. Nectins form cell-cell adhesion by their trans-interactions and recruit cadherins to the nectin-initiated cell-cell adhesion site to establish adherens junctions. Thereafter junction adhesion molecules, occludin, and claudins, are recruited to the apical side of adherens junctions to establish tight junctions. The recruitment of these molecules by nectins is mediated both by the direct and indirect interactions of afadin with many proteins, such as catenins, and zonula occludens proteins, and by the nectin-induced reorganization of the actin cytoskeleton. Nectins contribute to the formation of both homotypic and heterotypic types of cell-cell junctions, such as synapses in the brain, contacts between pigment and non-pigment cell layers of the ciliary epithelium in the eye, Sertoli cell-spermatid junctions in the testis, and sensory cells and supporting cells in the sensory organs. In addition, cis- and trans-interactions of nectins with various cell surface proteins, such as integrins, growth factor receptors, and nectin-like molecules (Necls) play important roles in the regulation of many cellular functions, such as cell polarization, movement, proliferation, differentiation, survival, and cell sorting. Furthermore, the Ig-CAMs are implicated in many human diseases including viral infections, ectodermal dysplasia, cancers, and Alzheimer's disease.