Vancomycin for Treatment of Bacterial Meningitis
Vancomycin for Treatment of Bacterial Meningitis
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万古霉素治疗细菌性脑膜炎
DOI：
10.1093/clinids/3.supplement_2.s289
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发表时间：
1981
影响因子：
11.8
通讯作者：
D. Gump
中科院分区：
文献类型：
--
作者：
D. Gump
摘要万古霉素治疗细菌性脑膜炎的临床经验尚不广泛。目前的资料表明，当存在脑膜炎症时，静脉注射万古霉素会渗透到脑脊液中，并且在脑脊液中的药物往往达到治疗有效水平。万古霉素治疗脑膜炎在临床情况下是有效的，这些情况排除了常用药物的使用，即耐药菌株或特殊微生物引起的感染，对青霉素过敏的患者，以及首选抗生素治疗失败的患者。当对静脉注射万古霉素的反应不满意时，在一些患者中加用鞘内治疗可获得良好的结果。与万古霉素协同作用的药物联合治疗是有益的。万古霉素值得认真考虑作为治疗细菌性脑膜炎的有效替代抗生素。
Abstract Clinical experience with vancomycin for the treatment of bacterial meningitis has not been extensive. Presently available data indicate that when meningeal inflammation is present intravenously administered vancomycin penetrates into cerebrospinal fluid and therapeutically effective levels of drug therein are frequently attained. Treatment of meningitis with vancomycin has been effective in clinical situations that precluded the use of the commonly administered agents, i.e., in infections due to resistant strains or to unusual organisms, in patients allergic to penicillin, and in patients for whom therapy with a first-choice antibiotic has failed. When response to intravenously administered vancomycin was unsatisfactory, the addition of intrathecal therapy resulted in a favorable outcome in some patients. Combination therapy with agents that act synergistically with vancomycin has been beneficial. Vancomycin warrants serious consideration as a useful alternate antibiotic for the treatment of bacterial meningitis.