COMPLETE NUCLEOTIDE-SEQUENCE OF AN INFLUENZA-VIRUS HEMAGGLUTININ GENE FROM CLONED DNA
COMPLETE NUCLEOTIDE-SEQUENCE OF AN INFLUENZA-VIRUS HEMAGGLUTININ GENE FROM CLONED DNA
复制标题
DOI：
10.1038/282471a0
复制
发表时间：
1979-01-01
期刊：
影响因子：
64.8
通讯作者：
EMTAGE, JS
中科院分区：
文献类型：
--
作者：
PORTER, AG;BARBER, C;EMTAGE, JS
在细菌[大肠杆菌]中克隆了合成的禽斑病毒（FPV）血凝素基因，并推导出RNA基因的完整序列。它是1742个核苷酸长和mRNA编码563个氨基酸在一个不间断的序列。血凝素中的一些重要结构域的性质被建立，并讨论了它们的结构与功能的关系。FPV和人流感血凝素之间存在广泛的氨基酸序列同源性。
A synthetic fowl plaque virus (FPV) hemagglutinin gene was cloned in bacteria [Escherichia coli] and the complete sequence of the RNA gene deduced. It is 1742 nucleotides long and the mRNA codes for 563 amino acids in an uninterrupted sequence. The nature of some of the important domains in the hemagglutinin was established, and their structure is discussed in relation to their function. Extensive amino acid sequence homologies exist between FPV and human influenza hemagglutinins.