The dark side of the NGF family:: Neurotrophins in neoplasias
The dark side of the NGF family:: Neurotrophins in neoplasias
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DOI：
10.1111/j.1750-3639.2006.00037.x
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发表时间：
2006-10-01
期刊：
影响因子：
6.4
通讯作者：
Weis, Joachim
中科院分区：
文献类型：
--
作者：
Kruettgen, Alex;Schneider, Imke;Weis, Joachim
虽然神经生长因子（NGF）家族的神经营养因子以其对神经元细胞的轴突生长诱导和存活促进作用而闻名，但这些实际上是生理上作用于我们身体的许多不同细胞类型的多效性生长因子。与许多其他生长因子一样，在许多肿瘤中发现神经营养因子信号转导失调，它们可以伴随或促成恶性转化。有趣的是，原肌球蛋白相关激酶（Trk）受体激活可以支持或抑制肿瘤生长，这取决于肿瘤类型。在神经营养因子与肿瘤细胞上的p75（NTR）神经营养因子受体结合的情况下，已经观察到这些相同的不同反应。本文总结了神经营养因子及其受体在恶性肿瘤中的作用，特别关注神经病理学意义的肿瘤。
Although neurotrophins of the nerve growth factor (NGF) family are best known for their neurite outgrowth-inducing and survival-promoting effects on neuronal cells, these are actually pleiotropic growth factors acting physiologically on many different cell types of our body. As for many other growth factors, dysregulation of neurotrophin signal transduction is found in a number of tumors where they can accompany or contribute to malignant transformation. Interestingly, tropomyosin-related kinase (Trk) receptor activation can either support or suppress tumor growth, depending on the tumor type. These same divergent responses have been observed with neurotrophins binding to the p75(NTR) neurotrophin receptor on tumor cells. This article summarizes the current knowledge on the role of neurotrophins and their receptors in malignancies, with special focus on tumors of neuropathological interest.