Mucin 13: structure, function, and potential roles in cancer pathogenesis.
Mucin 13: structure, function, and potential roles in cancer pathogenesis.
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DOI：
10.1158/1541-7786.mcr-10-0443
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Chauhan SC
中科院分区：
文献类型：
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作者：
Maher DM;Gupta BK;Nagata S;Jaggi M;Chauhan SC
Mucin 13 （MUC13）是一种高分子量的跨膜糖蛋白，在多种上皮癌中频繁和异常表达，包括胃癌、结直肠癌和卵巢癌。基于MUC13在癌细胞中的高表达，以及最近的实验室发现表明MUC13转染细胞系的恶性表型，MUC13的致癌潜力已经出现。MUC13的各种功能域可能赋予MUC13致癌潜能。例如，具有广泛聚糖链修饰的庞大的细胞外结构域可能会阻止细胞-细胞和细胞-细胞外基质的结合，而含有丝氨酸和酪氨酸残基的细胞质尾部可能参与细胞信号传导。MUC13具有适合作为癌症筛查早期标记物的特征，并为抗体引导的靶向治疗提供了一个有希望的靶点。
Mucin 13 (MUC13) is a high-molecular-weight transmembrane glycoprotein that is frequently and aberrantly expressed in a variety of epithelial carcinomas, including gastric, colorectal, and ovarian cancers. On the basis of the high expression of MUC13 in cancer cells as well as recent laboratory findings suggesting a malignant phenotype of MUC13-transfected cell lines, the oncogenic potential of MUC13 has emerged. The various functional domains of MUC13 may confer oncogenic potential to MUC13. For example, the bulky extracellular domain with extensive modification with glycan chains may prevent cell–cell and cell–extracellular matrix binding whereas the cytoplasmic tail containing serine and tyrosine residues for potential phosphorylation may participate in cell signaling. MUC13 exhibits the characteristics suitable as an early marker for cancer screening and presents a promising target for antibody-guided targeted therapy.