De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy.
De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy.
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DOI:
10.1038/sj.bjc.6605007
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发表时间:
2009-05-05
影响因子:
8.8
通讯作者:
Tsuruo, T.
中科院分区:
文献类型:
--
作者:
Mashima, T.;Seimiya, H.;Tsuruo, T.
Enhanced lipid biosynthesis is a characteristic feature of cancer. Deregulated lipogenesis plays an important role in tumour cell survival. These observations suggest that enzymes in the lipid synthesis pathway would be rational therapeutic targets for cancer. To this end, we review the enzymes in de novo fatty-acid synthesis and related pathways.
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DOI:
10.1038/labinvest.2008.97
发表时间:
2008-12
期刊:
Laboratory investigation; a journal of technical methods and pathology
影响因子:
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作者:
通讯作者:
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影响因子:
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作者:
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DOI:
10.1073/pnas.0403390101
发表时间:
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