A physiologically based pharmacokinetic model for theophylline disposition in the pregnant and nonpregnant rat
A physiologically based pharmacokinetic model for theophylline disposition in the pregnant and nonpregnant rat
复制标题
妊娠和非妊娠大鼠茶碱分布的基于生理学的药代动力学模型
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
L. Nordström
中科院分区：
文献类型：
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作者：
J. Gabrielsson;L. Paalzow;L. Nordström
有许多研究从传统的观点来考察茶碱的处置。然而，当通过生理流动模型研究动力学时，关于药物（包括茶碱）的行为的信息非常稀少。本研究旨在建立茶碱在未孕大鼠和妊娠大鼠体内药代动力学的预测分析模型。该模型假设特定的器官或组织块可以由其元件具有生理特性的隔室来模拟，例如，组织体积、血流和代谢活动。已经开发了具有血液、脑、肝、肌肉、肺、肾和胎儿组织的模型。除少数例外情况外，妊娠和非妊娠大鼠的预测和计算组织数据之间的一致性良好。最后，进行模型模拟以研究不同肺提取率对“假设”人类患者中茶碱浓度-时间曲线的影响。
There are numerous studies which examine the disposition of theophylline from a traditional point of view. Information about the behaviour of drugs, including theophylline, is, however, very scarce when investigating the kinetics by means of a physiological flow model. This study is concerned with the development of a predictive analytical model for the pharmacokinetics of theophylline in nonpregnant and pregnant rats. This model postulates that specific organ or tissue masses may be simulated by compartments whose elements have physiological properties, e.g., tissue volumes, blood flow, and metabolic activity. A model has been developed that has blood, brain, hepatic, muscular, pulmonary, renal, and fetal tissues. With few exceptions, the agreement was good between predicted and calculated tissue data in the pregnant and nonpregnant rats. Finally, model simulations were performed to investigate the impact of different pulmonary extraction ratios on the concentration-time profile of theophylline in a “hypothetical” human patient.
胎儿和新生儿接触药物的药代动力学。
影响因子：
7.2
作者：
Levy,G
通讯作者：
Levy,G