Wild birds do not harbor higher diversity of influenza virus internal genes than poultry
Wild birds do not harbor higher diversity of influenza virus internal genes than poultry
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野生鸟类的流感病毒内部基因多样性并不比家禽更高
DOI：
10.1016/j.virol.2019.02.003
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发表时间：
2019
期刊：
影响因子：
3.7
通讯作者：
Guan-Zhu Han
中科院分区：
文献类型：
--
作者：
Tian Zhang;Huayao Zhao;Jianhua Wang;Guan-Zhu Han
禽流感病毒（Avian influenza A virus，AIV）已严重威胁全球经济和公共健康。长期以来，野生鸟类被认为是流感病毒的天然宿主，因此预计野生鸟类比家禽具有更高的病毒多样性。然而，这一假设尚未得到正式验证。在这里，我们收集了来自全球75个地区超过11年的AIV数据集，并比较了野鸟AIV与家禽AIV的遗传多样性。野生鸟类AIV内部基因的遗传多样性并不显著高于家禽。我们建议，意想不到的多样性模式的AIV内部基因可以解释的AIV内部基因发生在19世纪末的同步全球扫描和野生鸟类和家禽之间的频繁AIV传播。我们的发现可能对理解流感病毒的进化具有重要意义。
Avian influenza A virus (AIV) has threatened global economy and public health. Wild birds have long been thought to serve as the natural reservoir of influenza virus, and thus it is expected that wild birds harbor higher viral diversity than poultry. Yet, this hypothesis has not been formally tested. Here, we assemble a data set of AIV from 75 regions worldwide over 11 years and compare the genetic diversity of wild bird AIV with that of poultry AIV. We find the genetic diversity of the internal genes of AIV in wild birds is not significantly higher than that in poultry. We propose that the unexpected diversity pattern of AIV internal genes could be explained by the synchronized global sweep of AIV internal genes occurring in the late 1800s and frequent AIV transmission between wild birds and poultry. Our findings might have important implications in understanding the evolution of influenza virus.