OSTEOCLASTS AND OSTEOBLASTS MIGRATE IN OPPOSITE DIRECTIONS IN RESPONSE TO A CONSTANT ELECTRICAL-FIELD
OSTEOCLASTS AND OSTEOBLASTS MIGRATE IN OPPOSITE DIRECTIONS IN RESPONSE TO A CONSTANT ELECTRICAL-FIELD
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DOI：
10.1002/jcp.1041290303
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发表时间：
1986-12-01
影响因子：
5.6
通讯作者：
AUBIN, JE
中科院分区：
文献类型：
--
作者：
FERRIER, J;ROSS, SM;AUBIN, JE
我们在体外研究了恒定电流产生的电场对新鲜分离的兔破骨细胞和已明确表征的克隆大鼠成骨细胞的影响。在 0.1 和 1 V/mm 的场强下，破骨细胞快速向正极迁移，而成骨细胞样细胞则沿相反方向向负极迁移。因此，来自同一组织的不同细胞类型对同一电信号的反应可能不同。 这些结果对于有关趋电流的细胞机制的假设具有重要意义，并且还可能阐明电刺激骨愈合的临床应用的细胞基础。
We have investigated in vitro the effects of the electrical field produced by constant current on freshly isolated rabbit osteoclasts and on well characterized clonal rat osteoblastlike cells. At field strengths of 0.1 and 1 V/mm, the osteoclasts migrated rapidly toward the positive electrode, whereas the osteoblastlike cells migrated in the opposite direction, toward the negative electrode. Thus, different cell types from the same tissue can respond differently to the same electrical signal. These results have important implications for hypotheses concerning the cellular mechanism of galvanotaxis, and may also clarify the cellular basis of the clinical application of electrical stimulation of bone healing.