Intrinsic and task-evoked network architectures of the human brain.

Intrinsic and task-evoked network architectures of the human brain.
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DOI:
10.1016/j.neuron.2014.05.014
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发表时间:
2014-07-02
期刊:
影响因子:
16.2
通讯作者:
Petersen SE
Petersen SE
中科院分区:
医学1区
文献类型:
--
作者:
Cole MW;Bassett DS;Power JD;Braver TS;Petersen SE

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在休息和任务状态下,人类大脑的许多功能网络特性已经被确定,但仍不清楚两者之间的关系。我们确定了一个全脑网络架构,该架构存在于数十种任务状态中,与静息状态网络架构高度相似。最常见的功能连接强度在任务中密切匹配的强度在休息时观察到的,这表明这是一个“内在的”,功能性大脑组织的标准架构。此外,一组小的,但一致的变化共同的任务表明存在一个任务一般的网络架构区分任务状态休息。这些结果表明,在任务执行过程中,大脑的功能网络结构主要是由一个内在的网络结构,也存在于休息,其次是由诱发的任务一般和特定任务的网络变化。这在静息状态功能连接和任务诱发功能连接之间建立了强有力的关系-神经科学研究的领域通常被单独考虑。
Many functional network properties of the human brain have been identified during rest and task states, yet it remains unclear how the two relate. We identified a whole-brain network architecture present across dozens of task states that was highly similar to the resting-state network architecture. The most frequent functional connectivity strengths across tasks closely matched the strengths observed at rest, suggesting this is an “intrinsic”, standard architecture of functional brain organization. Further, a set of small but consistent changes common across tasks suggests the existence of a task-general network architecture distinguishing task states from rest. These results indicate the brain’s functional network architecture during task performance is shaped primarily by an intrinsic network architecture that is also present during rest, and secondarily by evoked task-general and task-specific network changes. This establishes a strong relationship between resting-state functional connectivity and task-evoked functional connectivity – areas of neuroscientific inquiry typically considered separately.
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