Quantitative assessment of hyperacute cerebral infarction with intravoxel incoherent motion MR imaging: Initial experience in a canine stroke model
Quantitative assessment of hyperacute cerebral infarction with intravoxel incoherent motion MR imaging: Initial experience in a canine stroke model
复制标题
体素内不相干运动磁共振成像对超急性脑梗塞的定量评估：犬中风模型的初步经验。
DOI：
10.1002/jmri.25556
复制
发表时间：
2017-08-01
影响因子：
4.4
通讯作者：
Shi, Hai-Bin
中科院分区：
文献类型：
--
作者：
Gao, Qian-Qian;Lu, Shan-Shan;Shi, Hai-Bin
目的评价体素内非相干运动(IVIM)检测超急性卒中患者弥散和血流参数的可行性。材料与方法20只Beagle犬建立自体血栓栓塞性脑缺血模型。分别于栓塞后4.5h和6h在3.0Tesla平台上进行IVIM成像。用双指数模型拟合出10个b值在0~900 S/mm(2)范围内的血流灌注分数f、扩散系数D和拟扩散系数D*。此外，所有b值均采用单指数模型计算表观扩散系数。结果栓塞术后4.5h和6h，缺血区的f和D均较对侧显著降低(P
PurposeTo evaluate the feasibility of intravoxel incoherent motion (IVIM) for the measurement of diffusion and perfusion parameters in hyperacute strokes.Materials and MethodsAn embolic ischemic model was established with an autologous thrombus in 20 beagles. IVIM imaging was performed on a 3.0 Tesla platform at 4.5h and 6h after embolization. Ten b values from 0 to 900 s/mm(2) were fitted with a bi-exponential model to extract perfusion fraction f, diffusion coefficient D, and pseudo-diffusion coefficient D*. Additionally, the apparent diffusion coefficient (ADC) was calculated using the mono-exponential model with all the b values. Statistical analysis was performed using the pairwise Student's t test and Pearson's correlation test.ResultsA significant decrease in f and D was observed in the ischemic area when compared with those in the contralateral side at 4.5h and 6h after embolization (P