Expression of Epidermal Growth Factor Receptors in Human Endometrial Carcinoma
Expression of Epidermal Growth Factor Receptors in Human Endometrial Carcinoma
复制标题
表皮生长因子受体在人子宫内膜癌中的表达
DOI：
10.1097/00004347-199307000-00007
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发表时间：
1993
影响因子：
2.4
通讯作者：
B. Ottesen
中科院分区：
文献类型：
--
作者：
Henrik Christian Juul Nyholm;A. L. Nielsen;B. Ottesen
摘要 关于人类子宫内膜癌中表皮生长因子受体 (EGF-R) 表达的数据很少。在 65 名子宫内膜癌患者和 26 名患有非恶性绝经后子宫内膜（非活跃/萎缩子宫内膜或腺瘤性增生）的女性中研究了 EGF-R 状态。通过间接免疫过氧化物酶技术，使用抗 EGF-R 外部结构域的单克隆抗体，在冰冻组织切片上鉴定 EGF-R。 71% 的癌症表达阳性 EGF-R 免疫反应性。一般来说，染色在细胞膜上最为显着，在不同的癌症中具有不同的模式。 EGF-R表达与肿瘤邻近组织切片中免疫组织化学或生物化学评估的组织学分级、手术分期或雌激素/孕激素受体状态不相关。 13 个萎缩/不活跃子宫内膜中的 10 个（77%）和 13 个腺瘤性增生子宫内膜中的 7 个（54%）呈 EGF-R 阳性，其免疫染色模式与癌非常相似。
SummaryLittle data exist on the expression of epidermal growth factor receptors (EGF-Rs) in human endometrial cancer. EGF-R status was studied in 65 patients with endometrial carcinomas and in 26 women with nonmalignant postmenopausal endometria, either inactive/atrophic endometrium or adenomatous hyperplasia. EGF-R was identified on frozen tissue sections by means of an indirect immunoperoxidase technique with a monoclonal antibody against the external domain of the EGF-R. Seventy-one percent of the carcinomas expressed positive EGF-R immunoreactivity. In general, staining was most prominent at the cell membranes, with a varying pattern in individual carcinomas. EGF-R expression was not correlated with histologie grade, surgical stage, or estrogen/progesterone receptor status evaluated immunohisto-chemically or biochemically in adjacent tissue sections of the tumor. Ten of 13 (77%) atrophic/inactive endometria and seven of 13 (54%) endometria with adenomatous hyperplasia were EGF-R positive, with an immunostaining pattern rather similar to that of the carcinomas.