Sex-dependent effects of delta 9-tetrahydrocannabinol on locomotor activity in mice.
Sex-dependent effects of delta 9-tetrahydrocannabinol on locomotor activity in mice.
复制标题
δ9-四氢大麻酚对小鼠运动活性的性别依赖性影响。
DOI：
10.1016/j.neulet.2003.08.050
复制
发表时间：
2003
影响因子：
2.5
通讯作者：
Wiley,JennyL
中科院分区：
文献类型：
--
作者：
Wiley,JennyL
Sex differences in the effects of several drugs of abuse have previously been demonstrated. The present study evaluated sex differences in the effects of acute and repeated dosing with Δ9-tetrahydrocannabinol on locomotor activity in male and female Swiss Webster (CFW) mice. Results showed that acute Δ9-tetrahydrocannibol (1–30 mg/kg) increased locomotor activity in female, but not in male, mice. Following 3 days of daily injections of 10 mg/kg Δ9-tetrahydrocannabinol, re-tests of the same doses of Δ9-tetrahydrocannabinol tested acutely showed that female mice continued to exhibit greater sensitivity to the stimulatory effects of Δ9-tetrahydrocannabinol than did male mice; however, higher doses were required to produce these increases, suggesting a modest degree of tolerance development. These results are consistent with those of previous studies in which cannabinoids were more potent at producing locomotor suppression and antinociception in female than in male rats.
