Novel chiral synthetic path to indolizidine and quinolizidine alkaloids by means of a samarium diiodide-promoted reductive carbon-nitrogen cleavage reaction : Synthesis of (+)-(8R, 8aR) -perhydro -8 -indolizidinol and (-)-deoxynupharidine
Novel chiral synthetic path to indolizidine and quinolizidine alkaloids by means of a samarium diiodide-promoted reductive carbon-nitrogen cleavage reaction : Synthesis of (+)-(8R, 8aR) -perhydro -8 -indolizidinol and (-)-deoxynupharidine
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DOI：
10.3987/com-06-s(o)9
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发表时间：
2006-12
期刊：
影响因子：
0.6
通讯作者：
M. Katoh;Hirotake Mizutani;T. Honda
中科院分区：
文献类型：
--
作者：
M. Katoh;Hirotake Mizutani;T. Honda
开发了吲哚里西啶和喹里西啶生物碱的新型手性合成方法，其中二碘化钐促进的碳-氮键断裂反应被用作关键步骤。该程序的应用导致了(+)-(8R,8aR)-全氢-8-吲哚西啶醇和(-)-脱氧茚啶的全合成。
Novel chiral synthetic procedures for indolizidine and quinolizidine alkaloids were developed, where a samarium diiodide-promoted carbon-nitrogen bond cleavage reaction was employed as a key step. Application of the procedure led to the total synthesis of (+)-(8R, 8aR)-perhydro-8-indolizidinol and (-)-deoxynupharidine.