Integrin signaling in atherosclerosis.
Integrin signaling in atherosclerosis.
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DOI：
10.1007/s00018-017-2490-4
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Orr AW
中科院分区：
文献类型：
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作者：
Finney AC;Stokes KY;Pattillo CB;Orr AW
动脉粥样硬化是一种影响大动脉的慢性脂质驱动的炎症性疾病，是世界上心血管疾病的主要原因。动脉粥样硬化过程中血管内膜的局部重塑涉及血管细胞表型的调节、细胞迁移和增殖的改变以及局部细胞外基质重塑的传播。所有这些反应都代表了细胞粘附受体整联蛋白家族的靶点。因此，整合素信号传导的改变影响动脉粥样硬化的多个方面，从最早的炎症诱导到晚期纤维化斑块的发展。整合素信号转导已被证明调节内皮表型，促进白细胞归巢，影响白细胞功能，并驱动平滑肌纤维增生性重塑。此外，血小板中的整合素信号传导有助于血栓性并发症，其通常驱动心血管疾病的临床表现。在这篇综述中，我们研究了整合素调节动脉粥样硬化斑块发展的现有文献，以及整合素作为限制心血管疾病及其并发症的潜在治疗靶点的适用性。
Atherosclerosis, a chronic lipid-driven inflammatory disease affecting large arteries, represents the primary cause of cardiovascular disease in the world. The local remodeling of the vessel intima during atherosclerosis involves the modulation of vascular cell phenotype, alteration of cell migration and proliferation, and propagation of local extracellular matrix remodeling. All of these responses represent targets of the integrin family of cell adhesion receptors. As such, alterations in integrin signaling affect multiple aspects of atherosclerosis, from the earliest induction of inflammation to the development of advanced fibrotic plaques. Integrin signaling has been shown to regulate endothelial phenotype, facilitate leukocyte homing, affect leukocyte function, and drive smooth muscle fibroproliferative remodeling. In addition, integrin signaling in platelets contributes to the thrombotic complications that typically drive the clinical manifestation of cardiovascular disease. In this review, we examine the current literature on integrin regulation of atherosclerotic plaque development and the suitability of integrins as potential therapeutic targets to limit cardiovascular disease and its complications.