Right anterior cingulate: A neuroanatomical correlate of aggression and defiance in boys
Right anterior cingulate: A neuroanatomical correlate of aggression and defiance in boys
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DOI：
10.1037/0735-7044.122.3.677
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发表时间：
2008-06-01
影响因子：
1.9
通讯作者：
Nopoulos, Peg
中科院分区：
文献类型：
--
作者：
Boes, Aaron D.;Tranel, Daniel;Nopoulos, Peg
情绪过程的变化可能会导致攻击性和挑衅行为。这项研究评估了大量儿童和青少年样本中的这些问题行为，并与在情绪处理中起重要作用的两个皮质区域（前扣带皮层（ACC）和腹内侧前额叶皮层（vmPFC））的体积相关。从社区招募了 117 名年龄在 7 岁至 17 岁之间的参与者（61 名男孩，56 名女孩）。使用家长和老师报告的儿科行为量表来测量攻击性和挑衅行为，并使用结构 MRI 生成体积测量值。回归分析表明，性别 X ACC 体积在预测攻击性和挑衅行为方面存在显着的交互作用，但 vmPFC 没有显着的结果。后续分析表明，攻击性和挑衅行为与男孩右 ACC 体积减少有关，而女孩左 ACC 体积无显着减少。这些结果与右 ACC 在神经解剖学上与男孩的攻击性和反抗行为相关的观点是一致的。作者根据其对理解反社会行为的神经相关性的影响讨论了这一发现。
Variation in emotional processes may contribute to aggressive and defiant behavior. This study assessed these problem behaviors in a large sample of children and adolescents in relation to the volume of two cortical regions with prominent roles in emotion processing, the anterior cingulate cortex (ACC) and ventromedial prefrontal cortex (vmPFC). One hundred seventeen participants (61 boys, 56 girls), ages 7-17, were recruited from the community. Aggressive and defiant behavior was measured using the parent- and teacher-reported Pediatric Behavior Scale and volumetric measures were generated using structural MRI. Regression analyses indicated a significant sex X ACC volume interaction in predicting aggressive and defiant behavior, without significant results for the vmPFC. Follow-up analyses showed that aggressive and defiant behavior is associated with decreased right ACC volume in boys and a nonsignificant reduction in left ACC volume in girls. These results are consistent with the notion that the right ACC acts as a neuroanatomical correlate of aggression and defiance in boys. The authors discuss this finding in light of its implications for understanding the neural correlates of antisocial behavior.