Plasticity of Burst Firing Induced by Synergistic Activation of Metabotropic Glutamate and Acetylcholine Receptors
Plasticity of Burst Firing Induced by Synergistic Activation of Metabotropic Glutamate and Acetylcholine Receptors
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DOI：
10.1016/j.neuron.2008.12.013
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发表时间：
2009-01-29
期刊：
影响因子：
16.2
通讯作者：
Spruston, Nelson
中科院分区：
文献类型：
--
作者：
Moore, Shannon J.;Cooper, Donald C.;Spruston, Nelson
下丘脑是海马体的主要传出通路，参与空间任务的记忆、药物滥用复发和颞叶癫痫发作。下丘脑锥体神经元表现出由峰后除极驱动的低阈值爆发式放电。在此，我们报道通过刺激下丘脑区的传入投射来调节爆发式放电。与突触可塑性不同，突触可塑性不需要突触去极化、AMPA或NMDA受体的激活，也不需要动作电位的激发。相反，增强爆发式放电需要第1组、第1亚型代谢型谷氨酸受体(MGluRs)和M胆碱型乙酰胆碱受体(MAChR)协同激活。当这两个受体中的任何一个被阻断时，爆发的抑制被揭示出来，而这反过来又被组1的5型mGluRs的拮抗剂阻断。这些结果表明，激活海马区谷氨酸能传入和内侧隔区胆碱能传入，可以强烈地双向调节下丘脑下丘的输出。
Subiculum, the primary efferent pathway of hippocampus, participates in memory for spatial tasks, relapse to drug abuse, and temporal lobe seizures. Subicular pyramidal neurons exhibit low-threshold burst firing driven by a spike afterdepolarization. Here we report that burst firing can be regulated by stimulation of afferent projections to subiculum. Unlike synaptic plasticity, burst plasticity not require synaptic depolarization, activation of AMPA or NMDA receptors, or action potential firing. Rather, enhancement of burst firing required synergistic activation of group 1, subtype 1 metabotropic glutamate receptors (mGluRs) and muscarinic acetylcholine receptors (mAChR). When either of these receptors was blocked, a suppression of bursting was revealed, which in turn was blocked by antagonists of group 1, subtype 5 mGluRs. These results indicate that the output of subiculum can be strongly and bidirectionally regulated by activation of glutamatergic inputs within the hippocampus and cholinergic afferents from the medial septum.