Comparison of viscoelastic, structural, and material properties of double-looped anterior cruciate ligament grafts made from bovine digital extensor and human hamstring tendons
Comparison of viscoelastic, structural, and material properties of double-looped anterior cruciate ligament grafts made from bovine digital extensor and human hamstring tendons
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DOI：
10.1115/1.1351889
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发表时间：
2001-04-01
影响因子：
1.7
通讯作者：
Howell, SM
中科院分区：
文献类型：
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作者：
Donahue, TLH;Gregersen, C;Howell, SM
由于易于获得、成本降低以及免于人类中的传染性疾病（例如肝炎和AIDS），在旨在改善前交叉韧带（ACL）重建手术的结果的体外实验中，使用来自农场动物的肌腱移植物作为人类肌腱移植物的替代物将是有利的。因此，本研究的目的是确定由两个环的牛总指伸肌肌腱组成的前交叉韧带（ACL）移植物是否具有与由人类半腱肌和股薄肌肌腱的双环组成的移植物相同的粘弹性、结构和材料特性。为了满足这一目标，从每种组织来源构建移植物。使用面积千分尺测量横截面积，然后在浸没在盐水浴中的同时使用材料测试系统牵拉每个移植物。使用两组肌腱移植物（n = 10），粘弹性测试进行了为期三天的时间，在此期间，恒定位移载荷松弛测试，其次是恒定振幅，循环载荷蠕变测试（第一天），恒定载荷蠕变测试（第二天），和增量循环载荷蠕变测试（第三天）。对两组不同的移植物（n = 8）进行载荷失效试验。当比较粘弹行为时，载荷衰减率或最终载荷（松弛测试）以及位移增加率或最终位移（蠕变测试）没有显着差异（p > 0.115）。为了比较趾部区域中的结构和材料性质（即， 0.261）。这两种移植物之间性质的任何差异对两种类型的体外实验结果的理论影响（即，手术变量对膝关节松弛度和固定器械结构特性的影响）进行了讨论。尽管评价的性质存在一些统计学差异，但这些差异不会转化为对实验中感兴趣的因变量的重要影响。因此，在两种类型的实验中，牛肌腱移植物可以替代人肌腱移植物。
Due to ready availability, decreased cost, and freedom from transmissible diseases in humans such as hepatitis and AIDS, it would be advantageous to use tendon grafts from farm animals as a substitute for human tendon grafts in in vitro experiments aimed at improving the outcome of anterior cruciate ligament (ACL) reconstructive surgery. Thus the objective of this study was to determine whether an anterior cruciate ligament (ACL) graft composed of two loops of bovine common digital extensor tendon has the same viscoelastic, structural, and material properties as a graft composed of a double loop of semitendinosus and gracillis tendons from humans. To satisfy this objective, grafts were constructed from each tissue source. The cross-sectional area was measured using an area micrometer, and each graft was then pulled using a materials testing system while submerged in a saline bath. Using two groups of tendon grafts (n = 10), viscoelastic tests were conducted over a three-day period during which a constant displacement load relaxation test was followed by a constant amplitude, cyclic load creep test (first day), a constant load creep test (second day), and an incremental cyclic load creep test (third day). Load-to-failure tests were performed on two different groups of grafts (n = 8). When the viscoelastic behavior was compared, there were no significant differences in the rate of load decay or the final load (relaxation test) and rates of displacement increase or final displacements (creep tests) (p > 0.115). To compare both the structural and material properties in the toe region (i.e., 0.261). The theoretical effect of any differences in properties between these two grafts on the results of two types of in vitro experiments (i.e., effect of surgical variables on knee laxity and structural properties of fixation devices) are discussed. Despite some statistical differences in the properties evaluated, these differences do not translate into important effects on the dependent variables of interest in the experiments. Thus the bovine tendon graft can be substituted for the human tendon graft in both types of experiments.