Steroid hormones as bactericidal agents to Helicobacter pylori
Steroid hormones as bactericidal agents to Helicobacter pylori
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DOI：
10.1111/j.1574-6968.2011.02239.x
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发表时间：
2011-05-01
影响因子：
2.1
通讯作者：
Hirai, Yoshikazu
中科院分区：
文献类型：
--
作者：
Hosoda, Kouichi;Shimomura, Hirofumi;Hirai, Yoshikazu
幽门螺杆菌是一种独特的细菌物种，它吸收各种类固醇作为膜脂质成分。然而，我们的研究小组最近发现，某些类固醇可能会损害H。幽门。在这项研究中，我们继续揭示，雌二醇，雄烯二酮，孕酮（PS）都有可能抑制H。幽门。在这三种类固醇激素中，孕酮表现出最有效的抗H。pylori作用。17 α-羟孕酮己酸酯（17 α PSCE）是一种合成孕酮衍生物，具有更强的抗H。幽门螺杆菌的作用比孕酮，而17 α-羟孕酮，一种天然孕酮衍生物，完全不能抑制生物体的生长。孕酮和17 α PSCE均能杀死H. pylori通过其溶菌作用。在所调查的5种细菌中，H. pylori是唯一对孕酮和17 α PSCE的杀菌作用敏感的物种。其他四个物种，大肠杆菌，铜绿假单胞菌，金黄色葡萄球菌和表皮葡萄球菌，都抵制这一行动。孕酮和游离胆固醇（FC）对H. pylori细胞综上所述，这些结果表明孕酮和FC可能与H. pylori细胞表面。我们预计这些发现将有助于新型抗H抗体的开发。幽门螺杆菌甾体药物。
Helicobacter pylori is a unique bacterial species that assimilates various steroids as membrane lipid components. Our group has recently found, however, that certain steroids may impair the viability of H. pylori. In this study, we go on to reveal that estradiol, androstenedione, and progesterone (PS) all have the potential to inhibit the growth of H. pylori. Of these three steroid hormones, progesterone demonstrated the most effective anti-H. pylori action. 17 alpha-hydroxyprogesterone caproate (17 alpha PSCE), a synthetic progesterone derivative, had a much stronger anti-H. pylori action than progesterone, whereas 17 alpha-hydroxyprogesterone, a natural progesterone derivative, completely failed to inhibit the growth of the organism. Progesterone and 17 alpha PSCE were both found to kill H. pylori through their bacteriolytic action. Among five bacterial species investigated, H. pylori was the only species susceptible to the bactericidal action of progesterone and 17 alpha PSCE. The other four species, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epiderimidis, all resisted this action. Progesterone and free-cholesterol (FC) obstructed each other's effects against the H. pylori cell. Taken in sum, these results suggest that progesterone and FC may bind to the identical region on the H. pylori cell surface. We expect these findings to contribute to the development of a novel anti-H. pylori steroidal agent.