American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Ethylene Glycol Poisoning. Ad Hoc Committee.
American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Ethylene Glycol Poisoning. Ad Hoc Committee.
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美国临床毒理学会乙二醇中毒治疗实践指南。
DOI：
10.1081/clt-100102445
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
W. Watson
中科院分区：
文献类型：
--
作者：
Heather D. Miller;D. Barceloux;E. Krenzelok;K. Olson;W. Watson
福美唑(4-甲基吡唑，4-MP，安替佐尔)是一种有效的乙醇脱氢酶抑制剂，最近被美国食品和药物管理局(FDA)批准用于乙二醇中毒的治疗。虽然乙醇是乙二醇中毒的传统解毒剂，但尚未有前瞻性的研究。此外，FDA还没有批准将乙醇用于这一目的。病例报告和一系列预期病例表明，静脉注射(Iv)每12小时给药一次福美唑可防止与乙二醇转化为有毒代谢物相关的肾脏损害和代谢异常。目前，还没有足够的数据来确定甲氧美唑和乙醇在乙二醇中毒治疗中的相对作用。福美唑在有效疗效、可预测的药代动力学、易给药和无不良反应方面明显优于乙醇，而乙醇在长期临床经验和获取成本方面明显优于福美唑。使用每种解毒剂的整体医疗成本比较需要进一步研究。
Fomepizole (4-methylpyrazole, 4-MP, Antizol) is a potent inhibitor of alcohol dehydrogenase that was approved recently by the US Food and Drug Administration (FDA) for the treatment of ethylene glycol poisoning. Although ethanol is the traditional antidote for ethylene glycol poisoning, it has not been studied prospectively. Furthermore, the FDA has not approved the use of ethanol for this purpose. Case reports and a prospective case series indicate that the intravenous (i.v.) administration of fomepizole every 12 hours prevents renal damage and metabolic abnormalities associated with the conversion of ethylene glycol to toxic metabolites. Currently, there are insufficient data to define the relative role of fomepizole and ethanol in the treatment of ethylene glycol poisoning. Fomepizole has clear advantages over ethanol in terms of validated efficacy, predictable pharmacokinetics, ease of administration, and lack of adverse effects, whereas ethanol has clear advantages over fomepizole in terms of long-term clinical experience and acquisition cost. The overall comparative cost of medical treatment using each antidote requires further study.
4-甲基吡唑处理后细胞色素 P-450 和 4-甲基吡唑结合谱的含量增加。
DOI：
10.1016/0006-291x(85)90295-5
发表时间：
1985
影响因子：
3.1
作者：
Feierman,DE;Cederbaum,AI
通讯作者：
Cederbaum,AI
4-甲基吡唑对大鼠安替比林清除的抑制作用。
影响因子：
6.1
作者：
Chow,HH;Hutchaleelaha,A;Mayersohn,M
通讯作者：
Mayersohn,M
健康人体中 4-甲基吡唑和乙醇之间的动力学相互作用。
DOI：
10.1111/j.1530-0277.1996.tb05255.x
发表时间：
1996
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Jacobsen,D;Sebastian,CS;Dies,DF;Breau,RL;Spann,EG;Barron,SK;McMartin,KE
通讯作者：
McMartin,KE