Controlling Biological Activity with Light: Diarylethene- Containing Cyclic Peptidomimetics
Controlling Biological Activity with Light: Diarylethene- Containing Cyclic Peptidomimetics
复制标题
DOI：
10.1002/anie.201310019
复制
发表时间：
2014-03-24
影响因子：
16.6
通讯作者：
Komarov, Igor V.
中科院分区：
文献类型：
--
作者：
Babii, Oleg;Afonin, Sergii;Komarov, Igor V.
自然界中的光生物学过程通常由非肽生色团或修饰的侧链引发。提出了一种系统，其中多肽骨架本身可以通过光进行构象转换。设计并合成了一种基于可逆光致异构二芳基乙烯骨架的氨基酸类似物。该类似物在几个位点被掺入到抗微生物肽短杆菌肽S的环状骨架中。所得肽模拟物的生物活性然后可以通过紫外/可见光在严格限定的空间和时间限制内有效地控制。
Photobiological processes in nature are usually triggered by nonpeptidic chromophores or by modified side chains. A system is presented in which the polypeptide backbone itself can be conformationally switched by light. An amino acid analogue was designed and synthesized based on a reversibly photoisomerizable diarylethene scaffold. This analogue was incorporated into the cyclic backbone of the antimicrobial peptide gramicidinS at several sites. The biological activity of the resulting peptidomimetics could then be effectively controlled by ultraviolet/visible light within strictly defined spatial and temporal limits.