Epigenetic regulation of neural stem cell fate during corticogenesis
Epigenetic regulation of neural stem cell fate during corticogenesis
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DOI：
10.1016/j.ijdevneu.2013.02.006
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发表时间：
2013-10-01
影响因子：
1.8
通讯作者：
Nakashima, Kinichi
中科院分区：
文献类型：
--
作者：
MuhChyi, Chai;Juliandi, Berry;Nakashima, Kinichi
大脑皮层占大脑的四分之三以上，是复杂的知觉和认知功能的结构基础。它是从排列在神经管中的普通多能神经干细胞(NSCs)发展而来的。神经干细胞的发育包括祖细胞扩增、神经发生和神经胶质形成的连续阶段，以及发育阶段的进展。有趣的是，神经干细胞坚定不移地走过所有这些阶段，并以一种时间上定义的和高度可预测的方式产生特定的神经细胞类型。在此，我们描述了在大脑皮层发育过程中决定神经干细胞分化进程和节奏的内在和外在因素，以及表观遗传修饰如何影响神经干细胞的动态特性。(C)2013年综合业务数字网。爱思唯尔有限公司出版。保留所有权利。
The cerebral cortex comprises over three quarters of the brain, and serves as structural basis for the sophisticated perceptual and cognitive functions. It develops from common multipotent neural stem cells (NSCs) that line the neural tube. Development of the NSCs encompasses sequential phases of progenitor expansion, neurogenesis, and gliogenesis along with the progression of developmental stages. Interestingly, NSCs steadfastly march through all of these phases and give rise to specific neural cell types in a temporally defined and highly predictable manner. Herein, we delineate the intrinsic and extrinsic factors that dictate the progression and tempo of NSC differentiation during cerebral cortex development, and how epigenetic modifications contribute to the dynamic properties of NSCs. (C) 2013 ISDN. Published by Elsevier Ltd. All rights reserved.