Inflammation Resolution: Implications for Atherosclerosis.
Inflammation Resolution: Implications for Atherosclerosis.
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DOI：
10.1161/circresaha.121.319822
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发表时间：
2022-01-07
影响因子：
20.1
通讯作者：
Doran AC
中科院分区：
文献类型：
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作者：
Doran AC
分解是一种积极的、高度协调的过程，它发生在对炎症的反应中，以限制组织损伤并促进修复。当解决方案失败时，炎症仍然存在。现在人们理解，未能解决是许多慢性炎症性疾病的主要潜在原因。在这里，我们将回顾动脉粥样硬化中主要的溶解失败，包括促炎和促溶解介质产生的失衡，死亡细胞的清除受损，以及有利于持续炎症的免疫细胞的功能变化。此外，我们将简要讨论作为可能的解决方案调节器而出现的新概念，并强调其对该领域的翻译意义。
Resolution is an active and highly coordinated process that occurs in response to inflammation in order to limit tissue damage and promote repair. When the resolution program fails, inflammation persists. It is now understood that failed resolution is a major underlying cause of many chronic inflammatory diseases. Here, we will review the major failures of resolution in atherosclerosis, including the imbalance of pro-inflammatory to pro-resolving mediator production, impaired clearance of dead cells, and functional changes in immune cells that favor ongoing inflammation. In addition, we will briefly discuss new concepts that are emerging as possible regulators of resolution and highlight the translational significance for the field.