Dietary flavonoid intake, total antioxidant capacity and lipid oxidative damage: A cross-sectional study of Iranian women
Dietary flavonoid intake, total antioxidant capacity and lipid oxidative damage: A cross-sectional study of Iranian women
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DOI：
10.1016/j.nut.2015.11.011
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发表时间：
2016-05-01
期刊：
影响因子：
4.4
通讯作者：
Edalati, Sareh
中科院分区：
文献类型：
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作者：
Alipour, Beitolah;Rashidkhani, Bahram;Edalati, Sareh
目的：尽管强有力的证据支持类黄酮的体外抗氧化潜力，但生理浓度的类黄酮对人体整体抗氧化状态的影响并不一致。本研究的目的是检查表面健康女性的总类黄酮消耗量、血清总抗氧化能力 (TAC) 和丙二醛 (MDA) 水平之间的横断面关联。方法：通过多阶段整群抽样，招募了 170 名 20 至 48 岁的女性。通过将食品与美国农业部类黄酮数据库进行匹配，使用半定量食物频率调查表（FFQ）估算了通常的膳食类黄酮摄入量。使用一般线性模型来比较类黄酮摄入量三分位数之间的生化参数。结果：随着膳食花青素摄入量从最低三分位数上升到最高三分位数，多变量调整后的平均 TAC 浓度显着从 1.08 增加到 1.28（P 趋势 = 0.01）。在调整水果和蔬菜摄入量以及抗氧化维生素后，这种关联仍然很显着（P-趋势 = 0.03）。总类黄酮和茶黄素摄入量最高的三分位数的 TAC 平均浓度高于最低三分位数的平均浓度，但没有线性趋势（P < 0.05）。膳食中以葡萄和茄子作为花青素主要食物来源的膳食摄入量与血清TAC之间存在统计学上显着的正相关关系（分别P=0.02和0.04）。 MDA 和类黄酮摄入量之间没有发现显着关联（P > 0.05）。结论：本研究的结果支持花青素对整体抗氧化状态的影响。然而，需要进一步的研究来证实这些观察到的关联。 (C) 2016 Elsevier Inc. 保留所有权利。
Objectives: Although strong evidence supports the antioxidant potential of flavonoids in vitro, the effect of flavonoids at physiological concentrations on the overall antioxidant status in humans is inconsistent. The aim of this study was to examine cross-sectional associations between total flavonoid consumption, serum total antioxidant capacity (TAC), and malondialdehyde (MDA) levels in apparently healthy women.Methods: Through a multistage cluster sampling, 170 women ages 20 to 48 y were recruited. The usual dietary flavonoid intake was estimated using a semiquantitive food frequency questionnaire (FFQ) by matching food items with the US Department of Agriculture flavonoid databases. General linear models were used to compare the biochemical parameters across tertiles of flavonoid intakes.Results: As dietary anthocyanin intake rose from the lowest to the highest tertile, the multivariate adjusted mean TAC concentrations significantly increased from 1.08 to 1.28 (P-trend = 0.01). This association was still significant after adjustment for fruit and vegetable intake and antioxidant vitamins (P-trend = 0.03). The highest tertile of total flavonoid intake and theaflavins had higher mean concentrations of TAC than did the lowest tertile, but there was no linear trend (P < 0.05). There were statistically significant positive relationships between dietary intake of grapes and eggplant as main food sources of anthocyanins and serum TAC (P = 0.02 and 0.04, respectively). No significant associations were found between MDA and flavonoids intakes (P > 0.05).Conclusions: The findings of the present study support the attribution of anthocyanins to overall antioxidant status. However, further research is needed to confirm these observed associations. (C) 2016 Elsevier Inc. All rights reserved.