Layers of opportunity: nanostructured polymer assemblies for the delivery of macromolecular therapeutics
Layers of opportunity: nanostructured polymer assemblies for the delivery of macromolecular therapeutics
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DOI：
10.1039/b517860f
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发表时间：
2006-04-07
期刊：
影响因子：
3.4
通讯作者：
Lynn, DM
中科院分区：
文献类型：
--
作者：
Lynn, DM
纳米结构聚合物组件的逐层制造方法有助于各个领域的薄膜和复合材料的设计。在这里，我们重点介绍了我们实验室最近在多层组件设计方面的贡献，这些组件可以在生理环境中可控且可预测地腐蚀，并允许对 DNA 等大分子治疗药物的管理进行空间和时间控制。我们的方法利用由可水解降解的聚胺制成的组件。我们将这项工作置于其他实验室最近取得的进展的背景下，并讨论了新的机会和联系，这些机会和联系说明了这些分层组件作为一种或多种治疗剂的受控释放平台的潜力。
Layer-by-layer approaches to the fabrication of nanostructured polymer assemblies have contributed to the design of thin films and composites of interest in a variety of areas. Here, we highlight recent contributions from our laboratory toward the design of multilayered assemblies that erode controllably and predictably in physiological environments and permit spatial and temporal control over the administration of macromolecular therapeutics, such as DNA. Our approach makes use of assemblies fabricated from hydrolytically degradable polyamines. We place this work in the context of recent progress from other laboratories and discuss new opportunities and connections that illustrate the potential of these layered assemblies as platforms for the controlled release of one or several therapeutic agents.