HEMATOPOIETIC COLONY STIMULATING FACTORS PROMOTE CELL-SURVIVAL BY SUPPRESSING APOPTOSIS
HEMATOPOIETIC COLONY STIMULATING FACTORS PROMOTE CELL-SURVIVAL BY SUPPRESSING APOPTOSIS
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DOI：
10.1038/343076a0
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发表时间：
1990-01-04
期刊：
影响因子：
64.8
通讯作者：
TAYLOR, DR
中科院分区：
文献类型：
--
作者：
WILLIAMS, GT;SMITH, CA;TAYLOR, DR
造血前体细胞的存活、分化、增殖和发育以及成熟血细胞的功能活性都受到集落刺激因子（CSF）的影响。由于造血细胞在缺乏适当CSF的情况下迅速死亡2，3，CSF或生长因子介导的细胞存活的促进对于这些因子所产生的所有其他效应是至关重要的。这种细胞存活的增强与增殖的刺激不同1，4。在这里，我们表明，死亡的造血前体细胞撤回有关CSF是由于活跃的细胞死亡5，6，或凋亡，表明CSF促进细胞存活的过程中抑制凋亡。前体细胞存活的正调控机制的存在对正常造血和肿瘤发生的调控都有重要意义。
THE survival, differentiation, proliferation and development of haemopoietic precursor cells and the functional activity of mature blood cells are all influenced by colony stimulating factors (CSFs)1. As haemopoietic cells rapidly die in the absence of appropriate CSF2,3, the promotion of cell survival mediated by CSFs, or growth factors, is fundamental to all the other effects exerted by these factors. This enhancement of cell survival is distinct from the stimulation of proliferation1,4. Here we show that the death of haemopoietic precursor cells on withdrawal of the relevant CSF is due to active cell death5,6, or apoptosis, indicating that CSFs promote cell survival by suppression of the process of apoptosis. The existence of a positive control mechanism regulating precursor cell survival has important implications both for the regulation of normal haemopoiesis and for tumorigenesis.