Hypothalamic-pituitary-adrenal axis and autonomic nervous system activity in disruptive children and matched controls.
Hypothalamic-pituitary-adrenal axis and autonomic nervous system activity in disruptive children and matched controls.
复制标题
破坏性儿童和匹配对照组的下丘脑-垂体-肾上腺轴和自主神经系统活动。
DOI：
10.1097/00004583-200011000-00019
复制
发表时间：
2000
影响因子：
13.3
通讯作者：
H. Engeland
中科院分区：
文献类型：
--
作者：
S. H. Goozen;Walter Matthys;Peggy T. Cohen;J. K. Buitelaar;H. Engeland
目标
OBJECTIVES
To investigate whether a pattern of lower autonomic nervous system (ANS) and hypothalamic-pituitary-adrenal (HPA) axis activity is found in children with disruptive behavior disorders (DBD) under nonstressful and stressful conditions, and whether such a pattern would correspond with their feelings of control and negative emotionality.
METHOD
The effects of stress were studied by comparing cortisol response, heart rate (HR), skin conductance level (SCL), and subjective feelings of 26 children with DBD and 26 matched normal controls. An additional 12 normal control children were studied in a nonstress control condition.
RESULTS
Baseline HR and SCL but not cortisol were lower in the DBD group. Stress significantly affected cortisol, HR, SCL, and negative moods, although children with DBD showed a weaker HPA stress response and the difference between the groups was greater under stress.
CONCLUSIONS
Children with DBD are characterized by lower ANS activity and HPA axis responsivity, but higher levels of emotional arousal. It is possible that in children with DBD the HPA axis and ANS, on the one hand, and their emotional arousal, on the other, are less well coordinated. It is speculated that this could be due to differences in genetic makeup or to stressful conditions during pre- or postnatal life.
对立挑衅和品行障碍：DSM-IV 需要解决的问题。
DOI：
10.1097/00004583-199205000-00023
发表时间：
1992
影响因子：
13.3
作者：
Lahey,BB;Loeber,R;Quay,HC;Frick,PJ;Grimm,J
通讯作者：
Grimm,J