Reply to 'Lactate as a major myokine and exerkine'.
Reply to 'Lactate as a major myokine and exerkine'.
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回复“乳酸作为主要的肌动因子和运动因子”。
DOI：
10.1038/s41574-022-00726-y
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Pandey,A
中科院分区：
文献类型：
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作者：
Chow,LisaS;Gerszten,RobertE;Taylor,JoanM;Pedersen,BenteK;vanPraag,Henriette;Trappe,Scott;Febbraio,MarkA;Galis,ZorinaS;Gao,Yunling;Haus,JacobM;Lanza,IanR;Lavie,CarlJ;Lee,Chih-Hao;Lucia,Alejandro;Moro,Cedric;Pandey,A
我们感谢对我们的评论的评论（周，LS等人，健康，恢复力和疾病中的免疫因子。内分泌学国家评审18，273-289（2022））1，由乔治布鲁克斯和同事关于乳酸作为主要的肌因子和运动因子（布鲁克斯，GA等人，乳酸作为主要的肌因子和运动因子。内分泌学国家评审网址：//doi. org/10.1038/s41574-022-00724-0（2022）2）。在我们的综述1中，我们提到乳酸是一种公认的肌细胞因子，其作用不仅仅是作为能量来源来介导运动相关效应，而且越来越多地被认识到3。乳酸盐可以在运动过程中介导组织间的通讯。乳酸盐的作用可以是自分泌的，如乳酸盐增强C2 C12细胞的肌生成4所例示。或者，乳酸可以以旁分泌或内分泌方式发挥作用，例如刺激人脂肪细胞释放TGFβ2 5，或在小鼠模型中激活CD 8+淋巴细胞以延迟多种癌症类型的肿瘤生长6。我们认识到，我们的综述1主要将乳酸描述为具有直接信号作用的运动因子;这种描述是本着与其它Exerkine的直接信令描述保持一致的精神。值得注意的是，2022年Nature论文描述了运动刺激的N-乳酰-苯丙氨酸（Lac-Phe）合成，作为抑制进食和减少肥胖的重要运动因子7。布鲁克斯等人的评论2进一步描述了乳酸盐在驱动运动诱导的适应中的代谢作用。这种扩张是受欢迎的，因为布鲁克斯在2020年评论8中将乳酸盐描述为“代谢的支点”。乳酸在运动反应中起着不可或缺的作用，除了直接信号外，对其影响的更具体描述也支持其宝贵的贡献。
We appreciate the commentary on our Review (Chow, LS et al. Exerkines in health, resilience and disease. Nat. Rev. Endocrinol. 18, 273–289 (2022)) 1 by George Brooks and colleagues regarding lactate as a major myokine and exerkine (Brooks, GA et al. Lactate as a major myokine and exerkine. Nat. Rev. Endocrinol. https://doi. org/10.1038/s41574-022-00724-0 (2022) 2). In our Review 1, we mentioned that lactate is a recognized myokine, whose role beyond serving as an energy source to mediate exercise-related effects is increasingly recognized 3. Lactate can mediate tissue-to-tissue communication during exercise. The effect of lactate can be autocrine, as exemplified by lactate enhancing the myogenesis of C2C12 cells 4. Alternatively, lactate can act in a paracrine or endocrine fashion, as exemplified by stimulation of TGFβ2 release from human adipocytes 5, or by activation of CD8+ lymphocytes in a mouse model to delay tumour growth across multiple cancer types 6.We recognize that our Review 1 primarily described lactate as an exerkine with direct signalling effects; this description was in the spirit of staying consistent with the direct-signalling descriptions of other exerkines. Notably, a 2022 Nature paper described exercise-stimulated synthesis of N-lactoyl-phenylalanine (Lac-Phe) as an important exerkine that suppressed feeding and reduced obesity 7. The commentary by Brooks et al. 2 further describes lactate’s metabolic effects in driving exercise-induced adaptions. This expansion is welcome, as Brooks describes lactate serving as a ‘fulcrum of metabolism’in a 2020 Review 8. Lactate has an integral role in the exercise response and a more fleshed-out description of its impact, beyond direct signalling, upholds its valuable contributions.