Self-Focused AIScN Film Ultrasound Transducer for Individual Cell Manipulation
Self-Focused AIScN Film Ultrasound Transducer for Individual Cell Manipulation
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用于单个细胞操作的自聚焦 AIScN 薄膜超声换能器
DOI：
10.1021/acssensors.6b00713
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发表时间：
2017-01-01
期刊：
影响因子：
8.9
通讯作者：
Shung, K. Kirk
中科院分区：
文献类型：
--
作者：
Zhu, Benpeng;Fei, Chunlong;Shung, K. Kirk
在生物物理学和细胞生物学领域，精确的细胞定位是必不可少的。由高聚焦超声换能器产生的声微束最近被研究用于粒子或细胞操纵。由于具有较好的压电性能，Sc掺杂的AIN薄膜被引入到高聚焦超声换能器中。利用溅射方法，设计、制造了一种基于自聚焦AIScN薄膜的器件，并在类似于230 MHz的频率下进行了表征。它有一个狭窄的横向横梁宽度（类似于8.2 μ m）。AIScN超声换能器不仅能够在蒸馏水中远程控制单个10 μ m聚苯乙烯微球，而且还能够在磷酸盐缓冲盐水中在数百微米范围内的二维范围内无接触地操纵单个10 μ m表皮样癌细胞。最重要的是，细胞操作是在连续模式下实现的，不需要开关操作。这些结果表明，自聚焦AIScN膜超声换能器在生物医学和分子生物学领域具有广阔的应用前景。
Precise cell positioning is indispensable in the fields of biophysics and cellular biology. Acoustic microbeam produced by a highly focused ultrasound transducer has recently been investigated for a particle or cell manipulation. By virtue of the relatively good piezoelectric property, Sc doped AIN film was introduced for a highly focused ultrasound transducer application. Using a sputtering approach, a self focused AIScN film based device has been designed, fabricated, and characterized at a frequency of' similar to 230 MHz. It had a narrow lateral beam width (similar to 8.2 mu m). The AIScN ultrasound transducer was not only shown to be capable of remote controlling a single 10 mu m polystyrene microsphere in distilled water, but also demonstrated to possess the capability to manipulate without contact individual 10 mu m epidermoid carcinoma cell in two dimensions within a range of hundreds of micrometers in phosphate buffered saline. Most importantly, the cell manipulation was realized in continuous mode and no switch-on and -off operation was needed. These results suggest that self-focused AIScN film ultrasound transducer is a promising candidate for biomedical and molecular biology applications.