Concise Review: Fat and Furious: Harnessing the Full Potential of Adipose-Derived Stromal Vascular Fraction.
Concise Review: Fat and Furious: Harnessing the Full Potential of Adipose-Derived Stromal Vascular Fraction.
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DOI：
10.1002/sctm.16-0337
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发表时间：
2017-04
影响因子：
6
通讯作者：
Kota DJ
中科院分区：
文献类型：
--
作者：
Dykstra JA;Facile T;Patrick RJ;Francis KR;Milanovich S;Weimer JM;Kota DJ
由于其自我更新、增殖和产生多谱系细胞的能力，成体干细胞在再生疗法中具有巨大的潜力，可以阻止和/或逆转退行性疾病，如糖尿病、心力衰竭、阿尔茨海默病等。然而，这些细胞亚群可以从不同的生态位中分离出来，每种细胞都具有不同的治疗应用潜力。基质血管部分（SVF）是一种富含干细胞和脂肪来源的细胞群，由于其能够分泌加速内源性修复的旁分泌因子、易于获取且缺乏已确定的主要不良反应，因此作为再生医学的治疗方法引起了人们的兴趣。因此，人们很容易理解为什么急于利用脂肪来源的 SVF 来治疗人类疾病。 SVF 可能比任何其他细胞制剂更快地进入全球临床，同时确定 SVF 安全性、有效性和最佳标准化临床程序所需的关键临床前研究正在进行中。在这里，我们将概述驱动这一现象的当前知识、其监管问题和现有研究，并提出潜在的未映射应用。干细胞转化医学 2017；6：1096–1108
Due to their capacity to self‐renew, proliferate and generate multi‐lineage cells, adult‐derived stem cells offer great potential for use in regenerative therapies to stop and/or reverse degenerative diseases such as diabetes, heart failure, Alzheimer's disease and others. However, these subsets of cells can be isolated from different niches, each with differing potential for therapeutic applications. The stromal vascular fraction (SVF), a stem cell enriched and adipose‐derived cell population, has garnered interest as a therapeutic in regenerative medicine due to its ability to secrete paracrine factors that accelerate endogenous repair, ease of accessibility and lack of identified major adverse effects. Thus, one can easily understand the rush to employ adipose‐derived SVF to treat human disease. Perhaps faster than any other cell preparation, SVF is making its way to clinics worldwide, while critical preclinical research needed to establish SVF safety, efficacy and optimal, standardized clinical procedures are underway. Here, we will provide an overview of the current knowledge driving this phenomenon, its regulatory issues and existing studies, and propose potential unmapped applications. Stem Cells Translational Medicine 2017;6:1096–1108