Haplotype probabilities in advanced intercross populations.
Haplotype probabilities in advanced intercross populations.
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DOI：
10.1534/g3.111.001818
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发表时间：
2012-02
期刊：
影响因子：
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通讯作者：
Broman KW
中科院分区：
文献类型：
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作者：
Broman KW
先进的互交群体，其中多个近交系随机交配多代，具有更高的遗传作图精度的优势，因为跨多代的重组事件的积累。相关设计包括异质群体设计和多样性异交群体设计。在本文中，我使用这些设计推导出常染色体和X染色体上的两个位点单倍型概率。这些单倍型概率提供了发展隐马尔可夫模型治疗缺失的基因型信息的关键数量。我进一步推导出这些群体中的图谱扩展，即随机染色体上重组断点的频率。
Advanced intercross populations, in which multiple inbred strains are mated at random for many generations, have the advantage of greater precision of genetic mapping because of the accumulation of recombination events across the multiple generations. Related designs include heterogeneous stock and the diversity outcross population. In this article, I derive the two-locus haplotype probabilities on the autosome and X chromosome with these designs. These haplotype probabilities provide the key quantities for developing hidden Markov models for the treatment of missing genotype information. I further derive the map expansion in these populations, which is the frequency of recombination breakpoints on a random chromosome.