Arterial-phase contrast-enhanced ultrasonography for evaluating anti-angiogenesis treatment: A pilot study
Arterial-phase contrast-enhanced ultrasonography for evaluating anti-angiogenesis treatment: A pilot study
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DOI：
10.3748/wjg.v17.i8.1045
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发表时间：
2011-02-28
影响因子：
4.3
通讯作者：
Imai, Yasuharu
中科院分区：
文献类型：
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作者：
Yoshida, Keiko;Hirokawa, Tomihiko;Imai, Yasuharu
目的：验证肿瘤实质组织动脉期超声造影（CEUS）是否有助于抗血管生成药物的评价。方法：对患有肝肿瘤的家兔进行超声造影，记录血管期结节最大直径的图像。进行图像分析以绘制肿瘤实质的时间强度曲线（TIC），该曲线设置了强度测量感兴趣区域的直径。计算 TIC 以获得峰值时间。强度 (TPI) 和 PI 的大小。兔子被随机分配到索拉非尼治疗组和对照组。两周后，再次进行相同的超声检查，并进行病理学检查，以评估索拉非尼对肝脏肿瘤的影响。结果：治疗组4只兔的肿瘤大小变化率较对照组降低（2.3 vs 7.9，P = 0.02）。治疗组的 TPI 显着延长（SonoVue 的比率为 3.1 vs 1.1，P = 0.07，Sonazoid 的比率为 2.0 vs 0.88，P = 0.09）。 PI 的大小没有显着变化。病理检查显示，治疗组毛细血管直径明显小于对照组（26.4 vs 42.8 μm，P=0.013）。结论：通过肿瘤组织动脉期TIC分析可以评价抗血管生成药物治疗肝肿瘤的疗效。 (C)2011年百事登。版权所有。
AIM: To verify whether arterial-phase contrast-enhanced ultrasonography (CEUS) of tumor parenchymal tissue is useful for evaluation of anti-angiogenesis agents.METHODS: Rabbits with liver tumor were subjected to CEUS, and images of the nodular maximal diameter in vascular phase were recorded. Image analysis was performed to plot the time intensity curve (TIC) at the tumor parenchyma, which set the diameter of the region of interest of intensity measurement. The TIC was calculated to obtain the time to peak. intensity (TPI) and the magnitude of PI. Rabbits were randomly assigned to a treatment group with sorafenib and a control group. Two weeks later, the same ultrasound examination was repeated followed by pathological testing to assess the effect of sorafenib on the liver tumor.RESULTS: In four rabbits in the treatment group, the rate of change of tumor size was decreased compared with that of the control (the rate 2.3 vs 7.9, P = 0.02). The TPI of the treatment group elongated significantly (the rate 3.1 vs 1.1, P = 0.07 for SonoVue, 2.0 vs 0.88, P = 0.09 for Sonazoid). The magnitude of PI showed no significant changes. In pathological examination, capillary diameters in the treatment group were significantly smaller than those in the control group (26.4 vs 42.8 mu m, P = 0.013).CONCLUSION: Analysis of the TIC in the arterial phase of tumor tissue could evaluate the efficacy of anti-angiogenesis drug treatment in liver tumor. (C) 2011 Baishideng. All rights reserved.