Zinc and glycemic control: A meta-analysis of randomised placebo controlled supplementation trials in humans
Zinc and glycemic control: A meta-analysis of randomised placebo controlled supplementation trials in humans
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DOI：
10.1016/j.jtemb.2012.08.001
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发表时间：
2013-01-01
影响因子：
3.5
通讯作者：
Samman, Samir
中科院分区：
文献类型：
--
作者：
Capdor, Jasmine;Foster, Meika;Samman, Samir
背景：锌代谢受损在包括心血管疾病和糖尿病在内的慢性疾病中很突出。锌有可能影响葡萄糖的稳态在动物和人类，因此影响2型糖尿病的风险mellitus.Methods：随机安慰剂对照试验的系统评价和荟萃分析进行，以确定锌的补充对空腹血糖，糖化血红蛋白，血清胰岛素和血清锌浓度的影响。结果：共纳入14篇文献（n = 3978例受试者）。在总体分析中，在补锌后观察到空腹血糖浓度小幅但具有统计学意义的降低（-0.19 +/- 0.08 mmol/L，P = 0.013）。补充锌的个体中HbA 1c有下降趋势（-0.64 +/-0.36%，P = 0.072）。未观察到对血清胰岛素浓度的显著影响。补充锌后血浆锌浓度显著增加（+4.03 +/-0.81 μ mol/L，P = 0.001）。在慢性代谢性疾病参与者的次要分析中（1型和2型糖尿病，代谢综合征和肥胖），锌补充剂产生更大的葡萄糖浓度降低（-0.49 +/- 0.11 mmol/L，P = 0.001）与在健康参与者中观察到的效果相比。补充锌后血糖浓度显著降低（尽管幅度不大）和HbA 1c降低的趋势表明，锌可能有助于慢性代谢疾病患者高血糖症的管理。(C)2012 Elsevier GmbH. All rights reserved.
Background: Impaired zinc metabolism is prominent in chronic disorders including cardiovascular disease and diabetes. Zinc has the potential to affect glucose homeostasis in animals and humans and hence impact the risk of type 2 diabetes mellitus.Methods: A systematic review and meta-analysis of randomised placebo controlled trials was conducted to determine the effect of zinc supplementation on fasting blood glucose, HbA1c, serum insulin and serum zinc concentrations. Relevant studies for inclusion were identified from a literature search of electronic databases up to July 2011.Results: Fourteen reports (n = 3978 subjects) were included in the meta-analysis. In the overall analysis, a small but statistically significant reduction in fasting glucose concentrations was observed (-0.19 +/- 0.08 mmol/L, P = 0.013) after zinc supplementation. HbA1c tended to decrease in zinc-supplemented individuals (-0.64 +/- 0.36%, P = 0.072). No significant effect was observed for serum insulin concentrations. Plasma zinc concentrations increased significantly following supplementation (+4.03 +/- 0.81 mu mol/L, P = 0.001). In secondary analyses of participants with chronic metabolic disease (types 1 and 2 diabetes mellitus, metabolic syndrome and obesity), zinc supplementation produced a greater reduction in glucose concentrations (-0.49 +/- 0.11 mmol/L, P = 0.001) compared to the effect that was observed in healthy participants.Conclusion: The significant albeit modest reduction in glucose concentrations and tendency for a decrease in HbA1c following zinc supplementation suggest that zinc may contribute to the management of hyperglycemia in individuals with chronic metabolic disease. (C) 2012 Elsevier GmbH. All rights reserved.