Deaths due to absence of an affordable antitoxin for plant poisoning
Deaths due to absence of an affordable antitoxin for plant poisoning
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DOI：
10.1016/s0140-6736(03)14415-7
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发表时间：
2003-09-27
期刊：
影响因子：
168.9
通讯作者：
Rajakanthan, K
中科院分区：
文献类型：
--
作者：
Eddleston, M;Senarathna, L;Rajakanthan, K
发展中国家严重缺乏负担得起的抗蛇毒血清和抗毒素。斯里兰卡于2001年7月推出了一种用于治疗夹竹桃中毒的抗地高辛抗毒素，但由于其成本，库存于2002年7月用完。我们研究了它的引入和退出对病死率的影响，并确定了它的成本效益。抗毒素显著降低了病死率;它的缺乏导致死亡人数增加了三倍。以目前每门课程2650美元的价格计算，每挽救一条生命的成本为10209美元，每生命年的成本为248美元。将抗毒素的价格降低到400美元，每获得一条生命的成本将降低到1137美元;进一步降低到103美元，每获得一条生命将节省资金。目前的运动应包括中毒和毒化治疗，以增加发展中国家负担得起的治疗的可得性。
There is a severe shortage of affordable antivenoms and antitoxins in the developing world. An anti-digoxin antitoxin for oleander poisoning was introduced in Sri Lanka in July, 2001, but because of its cost, stocks ran out in July, 2002. We looked at the effect of its introduction and withdrawal on case fatality, and determined its cost-effectiveness. The antitoxin strikingly reduced the case fatality; its absence resulted in a three-fold rise in deaths. At the present price of US$2650 per course, every life saved cost $10 209 and every life year cost $248. Reduction of the antitoxin's price to $400 would reduce costs to $1137 per life gained; a further reduction to $103 would save money for every life gained. Treatments for poisoning and envenoming should be included in the present campaign to increase availability of affordable treatments in the developing world.